Ulenusiran
Ulenusiran (AD-1395762) is an siRNA duplex molecule that targets and inhibits the expression of the SOD1 gene. Ulenusiran can be used to study SOD1-associated amyotrophic lateral sclerosis.
For research use only. We do not sell to patients.
- CAS No.: 3060048-39-4
- Formula: C472H618F4N165O289P43S8
- Molecular Weight:14891.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
SOD1 is a copper- and zinc-dependent superoxide dismutase primarily localized in the cytoplasm; it scavenges superoxide anion radicals and maintains cellular redox homeostasis, and mutations in its gene are a major cause of familial amyotrophic lateral sclerosis (ALS).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3060048-39-4
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Molecular Weight 14891.25
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Formula C472H618F4N165O289P43S8
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SMILES
[Ulenusiran]
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Synonyms
AD-1395762
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)