URB447
Based on 1 Customer Validation
URB447 is a peripherally restricted CB1 cannabinoid antagonist (IC50: 313 nM and 41 nM for rat CB1 and human CB2 receptor respectively ). URB447 lowers food intake and body-weight gain in mice without entering the brain or antagonizing central CB1-dependent responses. URB447 can be used for research of obesity.
For research use only. We do not sell to patients.
- Purity: 99.5%
- CAS No.: 1132922-57-6
- Formula: C25H21ClN2O
- Molecular Weight:400.90
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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CB1 313 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
41 nM
Compound: 8b, URB-447
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Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHO-K1 cells by liquid scintillation counting
Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHO-K1 cells by liquid scintillation counting
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[PMID: 19128970] |
URB447 (100 nM-30 μM) inhibits GTPγS binding induced by the CB agonist WIN55,212-2 (1 μM), with an EC50 of 4.9 μM in rat cerebellar membrane preparations[1].
URB447 (1 μM) inhibits β-adrenergic agonist Isoproterenol (10 μM) induced cAMP accumulation in Hek-293 cells stably expressing mouse CB2 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
URB447 (20 mg/kg, i.p.) blocks the analgesic effects of Methanandamide in Swiss mice, indicating URB447 inhibits peripheral CB1-mediated analgesia[1].
URB447 (20 mg/kg, i.p., once daily for 2 weeks) reduces food consumption and body-weight gain in obese ob/ob mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1132922-57-6
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Appearance Solid
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Molecular Weight 400.90
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Formula C25H21ClN2O
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Color Light yellow to yellow
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SMILES
O=C(C1=C(C)N(CC2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C1N)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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