IL2RB - interleukin 2 receptor subunit beta Gene

Also Known as CD122; IMD63; IL15RB; P70-75

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3560

About IL2RB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:37,125,838-37,175,118 (from NCBI)

This gene has 22 transcripts (splice variants), 281 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 33.2), lymph node (RPKM 19.6) and 14 other tissues.

Summary

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

IL2RB Products (3)

mRNA	Protein	Name
NM_000878.5	NP_000869.1	interleukin-2 receptor subunit beta precursor
NM_001346222.1	NP_001333151.1	interleukin-2 receptor subunit beta precursor
NM_001346223.2	NP_001333152.1	interleukin-2 receptor subunit beta precursor

Protein Preferred Names	Protein Names
interleukin-2 receptor subunit beta	CD122 antigen

IL2RB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL2RB	P14784	IL2	Homo sapiens	P60568	ITC	22446627
Intra	IL2RB	P14784	IL2	Homo sapiens	P60568	SPR	22446627
Intra	IL2RB	P14784	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	IL2RB	P14784	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	IL2RB	P14784	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	IL2RB	P14784	IL15	Homo sapiens	P40933	SPR	23104097

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL2RB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7784	IL-2R beta/CD122 Protein, Human (HEK293, Fc)	P14784 (A27-D239)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70631	IL-2R beta/CD122 Protein, Human (HEK293, His)	P14784 (A27-D239)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72386	IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi)	P14784 (A27-D239)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77594	IL-2R beta/CD122 Protein, Human (HEK293, His-Avi)	P14784/NP_000869.1 (A27-D239)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77715	IL2RB-IL2RG Heterodimer Protein, Human (HEK293, Fc)	P14784 (A27-T240)&P31785 (L23-A262)	≥ 90%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

IL2RB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84102	CD122 Antibody (YA3799)	FC, ELISA	Human
HY-P84102A	CD122 Antibody (YA3799)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	IMD63 Il2rb Deficiency Cd122 Deficiency Immunodeficiency 63 Interleukin 2 Receptor, Beta, Deficiency Of Deficiency Of Interleukin 2 Receptor Beta
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Oligoarticular Juvenile Idiopathic Arthritis	Oligoarticular Jia Pauciarticular Chronic Arthritis Juvenile Pauciarticular Chronic Arthritis
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Juvenile Polyarthritis Without Rheumatoid Factor Juvenile Rheumatoid Factor-Negative Polyarthritis Rheumatoid Factor-Negative Polyarticular Jia Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
Diphtheria	Corynebacterium Infections Corynebacterium Infection Diphtherial Infection Infection Due To Corynebacterium Diphtheriae
Tropical Spastic Paraparesis	Tropical Spastic Paraplegia Ham/Tsp Htlv-Associated Myelopathy Tropical Spastic Paralysis Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis Tsp Paraparesis Tropical Spastic Paraparesis, Tropical Spastic
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Hairy Cell Leukemia	Hcl-V Hairy Cell Leukemia Variant Hairy Cell Leukaemia Variant Hcl Leukemic Reticuloendotheliosis Leukemic Reticuloendotheliosis Variant Prolymphocytic Variant Of Hcl Prolymphocytic Variant Of Hairy Cell Leukemia Leukemia Hairy Cell Leukemia, Hairy Cell Leukaemic Reticuloendotheliosis Lre - [Leukemic Reticuloendotheliosis] Hairy-Cell Leukaemia, Nos Hcl - [Hairy Cell Leukaemia] Hairy-Cell Leukaemia Without Mention Of Remission
T-Cell Large Granular Lymphocyte Leukemia	Large Granular Lymphocytic Leukemia Proliferation Of Large Granular Lymphocytes T-Lgl T-Cell Lgl Leukemia Large Granular Lymphocytic Leukaemia T-Cell Large Granular Lymphocyte Leukaemia Large Cell Granular Lymphogenous Leukemia T-Lgl Leukemia Leukemia Lymphocytic Large Granular Leukemia, Large Granular Lymphocytic
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Posterior Uveitis	Uveitis, Posterior Choroiditis Uveitis Posterior
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Secondary Progressive Multiple Sclerosis	Secondary-Progressive Ms Spms Multiple Sclerosis, Chronic Progressive Chronic Progressive Multiple Sclerosis Multiple Sclerosis, Secondary Progressive
Berylliosis	Beryllium Poisoning Beryllium Disease Lung Fibrosis With Berylliosis
Boutonneuse Fever	Mediterranean Spotted Fever African Tick Typhus Boutonneuse Disease Conor And Bruch'S Disease Kenya Fever Kenya Tick Typhus Kenyan Tick Typhus Marseilles Fever Mediterranean Tick Fever Rickettsia Conorii Spotted Fever South African Tick-Bite Fever African Tick Bite Fever
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Pulmonary Sarcoidosis	Sarcoidosis, Pulmonary Lung Sarcoidosis Sarcoidosis Pulmonary Lung Sarcoid Sarcoidosis In Lung
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity	Cd25 Deficiency Immunodeficiency Due To Cd25 Deficiency IMD41 Interleukin 2 Receptor, Alpha, Deficiency Of Il2ra Deficiency Immunodeficiency 41 Interleukin-2 Receptor Alpha Chain Deficiency Interleukin 2 Receptor Alpha Deficiency Interleukin-2 Receptor, Alpha Chain, Deficiency Of Immunodeficiency, Type 41 With Lymphoproliferation And Autoimmunity
Shwartzman Phenomenon	Shwartzman Reaction
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Extrinsic Allergic Alveolitis	Hypersensitivity Pneumonitis Alveolitis, Extrinsic Allergic Alveolitis Allergic Interstitial Pneumonitis Allergic Pneumonitis Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis Hp Pneumonitis Hypersensitivity Allergic Alveolitis Extrinsic Allergic Alveolitis Nos Airway Obstruction With Allergic Alveolitis Unspecified Allergic Alveolitis And Pneumonitis Extrinsic Allergic Bronchiolo-Alveolitis Hypersensitivity Pneumonia Hypersensitivity Pneumonitis Nos Obstructive Lung Disease With Allergic Alveolitis Obstructive Lung Disorder With Hypersensitivity Pneumonitis Obstructive Lung Disorder With Allergic Alveolitis Obstructive Lung Disease With Hypersensitivity Pneumonitis
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Viral Hepatitis	Animal Viral Hepatitis Hepatitis, Viral, Animal Human Viral Hepatitis Viral Hepatitis With Hepatic Coma
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
B-Cell Expansion With Nfkb And T-Cell Anergy	Benta Disease BENTA B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease Persistent Polyclonal B-Cell Lymphocytosis Lymphocytosis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Type 1 Diabetes Mellitus 8	Diabetes Mellitus, Insulin-Dependent, 8 Iddm8 Insulin-Dependent Diabetes Mellitus 8 T1D8 Insulin-Dependent Diabetes Mellitus-8
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991279	Mik-Beta-1	Inhibitor	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06749	IL2RB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16278	Il2rb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17342	Il2rb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL2RB	RGD	RGD:2896
Macaca mulatta	IL2RB	VGNC	VGNC:73728
Felis catus	IL2RB	VGNC	VGNC:67777
Mus musculus	IL2RB	MGD	MGI:96550
Bos taurus	IL2RB	VGNC	VGNC:30152
Canis familiaris	IL2RB	VGNC	VGNC:41978
Others	IL2RB	NCBI