NCGC 607
Based on 1 publication(s) in Google Scholar
NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase). NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 1462267-07-7
- Formula: C24H22IN3O4
- Molecular Weight:543.35
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Neuronal Signaling Compound Library
HY-L013
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) NCGC 607
MoreAll α-synuclein Isoforms
More
Biological Activity
NCGC 607 (3 μM; 6 d) increases GCase activity, elevates GCase protein levels, and reduces glucosylceramide storage in macrophages[1].
NCGC 607 (3 μM; 21 d) decreases α-synuclein levels and reduces its colocalization with the lysosomal marker Lamp2 in dopaminergic neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:iPSC-derived macrophages (Gaucher disease model)
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Concentration:3 μM
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Incubation Time:6 days
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Result:Increased the level of GCase.
Chemical Information
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CAS No. 1462267-07-7
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Appearance Solid
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Molecular Weight 543.35
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Formula C24H22IN3O4
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Color White to off-white
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SMILES
O=C(NCC(N(C)C1=CC=CC=C1)=O)C2=CC=CC=C2OCC(NC3=CC=C(I)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
2025 Oct 23:117451. PMID: 41138926
Solvent & Solubility
DMSO : 62.5 mg/mL (115.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8404 mL | 9.2022 mL | 18.4043 mL | 46.0109 mL |
| 5 mM | 0.3681 mL | 1.8404 mL | 3.6809 mL | 9.2022 mL | |
| 10 mM | 0.1840 mL | 0.9202 mL | 1.8404 mL | 4.6011 mL | |
| 15 mM | 0.1227 mL | 0.6135 mL | 1.2270 mL | 3.0674 mL | |
| 20 mM | 0.0920 mL | 0.4601 mL | 0.9202 mL | 2.3005 mL | |
| 25 mM | 0.0736 mL | 0.3681 mL | 0.7362 mL | 1.8404 mL | |
| 30 mM | 0.0613 mL | 0.3067 mL | 0.6135 mL | 1.5337 mL | |
| 40 mM | 0.0460 mL | 0.2301 mL | 0.4601 mL | 1.1503 mL | |
| 50 mM | 0.0368 mL | 0.1840 mL | 0.3681 mL | 0.9202 mL | |
| 60 mM | 0.0307 mL | 0.1534 mL | 0.3067 mL | 0.7668 mL | |
| 80 mM | 0.0230 mL | 0.1150 mL | 0.2301 mL | 0.5751 mL | |
| 100 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4601 mL |
NCGC 607 Related Classifications
HY-120034 Related Classifications
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