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Cat. No.: HY-N18411

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Tanacetin

Tanacetin is a sesquiterpenoid compound discovered in the whole herb of Crossostephium chinense (L.) Makino. Sesquiterpene lactones, the class to which Tanacetin belongs (e.g., constituents of plants in the Tanacetum genus), inhibit the inflammatory mediators prostaglandins and leukotrienes. Tanacetin crosses intestinal cell monolayers primarily via transcellular passive diffusion, and no significant first-pass metabolism occurs during its intestinal absorption. Tanacetin is used in research related to diabetes, migraine, and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 1401-54-3
Formula: C₁₅H₂₀O₄
Molecular Weight:264.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tanacetin Chemical Structure

CAS No.: 1401-54-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Tanacetin (100 mg; 1 h at 65°C) treated with 0.9 mg NaOCH₃ in 100 mL MeOH converts it to crossostephin with a 20.1% yield, as confirmed by spectroscopic and optical rotation analysis^[1].
Tanacetin (10-200 μM; 30-180 min) is well absorbed across Caco-2 cell monolayers primarily via passive diffusion through the transcellular pathway, with an AP→BL P_app of 1.77×10^-5 cm/s and no significant first-pass metabolism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1401-54-3
Molecular Weight 264.32
Formula C₁₅H₂₀O₄
SMILES

O[C@@]12[C@]3([H])[C@@](C(C(O3)=O)=C)([H])CC[C@]1([C@@H](CCC2=C)O)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu Q, et al. Novel sesquiterpene and coumarin constituents from the whole herbs of Crossostephium chinense. J Asian Nat Prod Res. 2009;11(1):85-90.

[2]. Wu Q, et al. Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model. Planta medica. 2010 Mar;76(4):319-24.

[3]. Zou L, et al. [Effects of chemical constituents of Crossostephium chinense on insulin secretion in rat islets in vitro]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1401-5.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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