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Cat. No.: HY-110318R

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VUF11207 fumarate (Standard)

VUF11207 fumarate Standard is the analytical standard of VUF11207 fumarate (HY-110318). This product is intended for research and analytical applications. VUF11207 fumarate is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 fumarate specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 fumarate can be used for research on glioblastoma, hypertension, and venous thrombosis.

For research use only. We do not sell to patients.

CAS No.: 1785665-61-3
Formula: C₃₁H₃₉FN₂O₈
Molecular Weight:586.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VUF11207 fumarate (Standard) Chemical Structure

CAS No.: 1785665-61-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1785665-61-3
Molecular Weight 586.65
Formula C₃₁H₃₉FN₂O₈
SMILES

C/C(CN(C(C1=CC(OC)=C(C(OC)=C1)OC)=O)CCC2N(CCC2)C)=C\C3=C(C=CC=C3)F.OC(/C=C/C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nugraha AP, et al. C‑X‑C receptor 7 agonist acts as a C‑X‑C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. Molecular medicine reports. 2022 Mar;25(3):78. [Content Brief]

[2]. Liu CC, et al. CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity. Cell death & disease. 2024 Jun 19;15(6):434. [Content Brief]

[3]. Song B, et al. Stromal cell-derived factor-1 exerts opposing roles through CXCR4 and CXCR7 in angiotensin II-induced adventitial remodeling. Biochemical and biophysical research communications. 2022 Feb 26;594:38-45.

[4]. Dekkers S, et al. Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3). ACS medicinal chemistry letters. 2024 Jan 11;15(1):143-148.

[5]. Aslan JE. A platelet lipid switch that slows clotting. Blood. 2026 Sep 10;148(11):1379-80.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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