WCA-814
WCA-814 is an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate. WCA-814 induces the degradation of full-length and AR-V7. WCA-814 has cytotoxic effect in prostatic cancer cells (IC50: 171.2 nM, 26.5 nM for LNCaP, 22Rv1 cell).
For research use only. We do not sell to patients.
- CAS No.: 2951858-45-8
- Formula: C46H53ClN10O5
- Molecular Weight:861.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | IC50 |
26.5 nM
Compound: 6; WCA-814
|
Cytotoxicity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 5 days in presence of AR agonist, R1881 by WST-1 assay
Cytotoxicity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 5 days in presence of AR agonist, R1881 by WST-1 assay
|
[PMID: 36960664] |
| LNCaP | IC50 |
171.2 nM
Compound: 6; WCA-814
|
Cytotoxicity against AR-positive human LNCaP cells assessed as inhibition of cell growth incubated for 5 days in presence of AR agonist, R1881 in charcoal stripped serum by WST-1 assay
Cytotoxicity against AR-positive human LNCaP cells assessed as inhibition of cell growth incubated for 5 days in presence of AR agonist, R1881 in charcoal stripped serum by WST-1 assay
|
[PMID: 36960664] |
Chemical Information
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CAS No. 2951858-45-8
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Molecular Weight 861.43
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Formula C46H53ClN10O5
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SMILES
CC(C1=C(C=C(C(C2=NNC(N2C3=CC=C(C=C3)CN4CCN(CC4)CC5CCN(CC5)C6=CC=C(N=N6)C(N[C@H]7CC[C@@H](CC7)OC8=CC(Cl)=C(C=C8)C#N)=O)=O)=C1)O)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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