2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. WX-293

WX-293 is a highly selective urokinase-type plasminogen activator (uPA) inhibitor with a Ki value of 2.4 μM. WX-293 abolishes hypoxia-induced keratinocyte migration and in vitro wound closure. WX-293 can be used in research on hypoxia-mediated skin wounds and solid malignant tumors.

For research use only. We do not sell to patients.

WX-293

WX-293 Chemical Structure

CAS No. : 282718-42-7

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WX-293 Related Antibodies

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Description

WX-293 is a highly selective urokinase-type plasminogen activator (uPA) inhibitor with a Ki value of 2.4 μM. WX-293 abolishes hypoxia-induced keratinocyte migration and in vitro wound closure. WX-293 can be used in research on hypoxia-mediated skin wounds and solid malignant tumors[1][2].

In Vitro

WX-293 (0.1-0.2 μM; 16 h) inhibits hypoxia-induced in vitro wound healing of PAM 212 mouse keratinocytes in a concentration-dependent manner[1].
WX-293 potently and selectively inhibits purified human urokinase-type plasminogen activator (uPA) with a Ki value of 2.4 µM, and its mechanism of action involves targeting the S1′ pocket of uPA via a non-traditional binding mode[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WX-293 Related Antibodies

Cell Migration Assay [1]

Cell Line: PAM 212 murine keratinocytes
Concentration: 0.1 μM, 0.2 μM
Incubation Time: 16 h
Result: Inhibited hypoxia-enhanced wound closure by 70% (0.1 μM).
Inhibited uPA activity by 55.3% (0.1 μM).
Completely abolished hypoxia-enhanced wound closure (0.2 μM).
Inhibited uPA activity by 74.0% (0.2 μM).
Exhibited no effect on wound closure in normoxic cultures at either concentration.
Molecular Weight

341.45

Formula

C19H27N5O
CAS No.
SMILES

O=C(NC12CC3CC(C2)CC(C1)C3)NCC4=CC=C(NC(N)=N)C=C4
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Purity & Documentation
References
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WX-293 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WX-293282718-42-7WX293WX 293Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesuPAkeratinocyte migrationS1'-pocketurokinase plasminogen activatorPAM 212 murine keratinocytescutaneous wound healing impairmentsolid malignant tumoursInhibitorinhibitorinhibit

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