2. Apoptosis
  3. IAP
  4. XIAP degrader-1

XIAP degrader-1, a primary amine tethered small molecule, promotes the degradation of X-linked inhibitor of apoptosis protein (XIAP).

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XIAP degrader-1

XIAP degrader-1 Chemische Struktur

CAS. Nr. : 2803617-91-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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Based on 1 publication(s) in Google Scholar

XIAP degrader-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE XIAP degrader-1

Alle IAP Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
cIAP cIAP-1 cIAP-2 XIAP

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Beschreibung

XIAP degrader-1, a primary amine tethered small molecule, promotes the degradation of X-linked inhibitor of apoptosis protein (XIAP).

Molekulargewicht

587.75

Formel

C34H45N5O4
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN[C@H](C(N[C@@H]1C(N(C2=C(N([C@H]1C)C(CCCCCCCN)=O)C=CC=C2)CC3=C(C=CC=C4)C4=CC=C3OC)=O)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (170.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7014 mL 8.5070 mL 17.0140 mL
5 mM 0.3403 mL 1.7014 mL 3.4028 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7014 mL 8.5070 mL 17.0140 mL 42.5351 mL
5 mM 0.3403 mL 1.7014 mL 3.4028 mL 8.5070 mL
10 mM 0.1701 mL 0.8507 mL 1.7014 mL 4.2535 mL
15 mM 0.1134 mL 0.5671 mL 1.1343 mL 2.8357 mL
20 mM 0.0851 mL 0.4254 mL 0.8507 mL 2.1268 mL
25 mM 0.0681 mL 0.3403 mL 0.6806 mL 1.7014 mL
30 mM 0.0567 mL 0.2836 mL 0.5671 mL 1.4178 mL
40 mM 0.0425 mL 0.2127 mL 0.4254 mL 1.0634 mL
50 mM 0.0340 mL 0.1701 mL 0.3403 mL 0.8507 mL
60 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7089 mL
80 mM 0.0213 mL 0.1063 mL 0.2127 mL 0.5317 mL
100 mM 0.0170 mL 0.0851 mL 0.1701 mL 0.4254 mL
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XIAP degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XIAP degrader-12803617-91-4XIAP degrader1XIAP degrader 1IAPInhibitorinhibitorinhibit

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