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Cat. No.: HY-120376

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XZH-5

XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability.

For research use only. We do not sell to patients.

CAS No.: 1360562-98-6
Formula: C₂₂H₂₅F₆N₅O₄
Molecular Weight:537.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

XZH-5 Chemical Structure

CAS No.: 1360562-98-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability^[1].

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HPAC	IC₅₀	17.4 μM Compound: 1a	Cytotoxicity against human HPAC cells after 72 hrs by MTT assay Cytotoxicity against human HPAC cells after 72 hrs by MTT assay	[PMID: 25698618]
MDA-MB-231	IC₅₀	15.5 μM Compound: 1a	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 25698618]
PANC-1	IC₅₀	24.7 μM Compound: 1a	Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay	[PMID: 25698618]
SW1990	IC₅₀	17.9 μM Compound: 1a	Cytotoxicity against human SW1990 cells after 72 hrs by MTT assay Cytotoxicity against human SW1990 cells after 72 hrs by MTT assay	[PMID: 25698618]

Chemical Information

CAS No. 1360562-98-6
Molecular Weight 537.46
Formula C₂₂H₂₅F₆N₅O₄
SMILES

O=C(OC)[C@H](CC1=CN(C)C=N1)NC([C@H](C(C)C)NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Chenglong, et al. Compound XZH-5 inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human hepatocellular carcinoma cells. World Intellectual Property Organization, WO2012078982 A2 2012-06-14

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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References

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XZH-5

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

XZH-5 Related Classifications

HY-120376 Related Classifications