2. Immunology/Inflammation
  3. IFNAR
  4. YE6144 free base

YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research.

For research use only. We do not sell to patients.

YE6144 free base

YE6144 free base Chemical Structure

CAS No. : 3065657-01-1

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YE6144 free base Related Antibodies

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Description

YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research[1].

IC50 & Target[1]

IRF5

 

In Vitro

YE6144 (1 or 3 μM; 30 min) free base inhibits the phosphorylation of IRF5 in both human PBMCs and mouse splenocytes[1].
YE6144 (0-10 μM; 30 min) free base inhibits the production of type I IFNs with an IC50 of approximately 0.09 μM in human HC PBMCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YE6144 free base Related Antibodies

Western Blot Analysis[1]

Cell Line: Human HC PBMCs and mouse WT splenocytes
Concentration: 1 μM (PBMCs) and 3 μM (splenocytes)
Incubation Time: 30 min
Result: Inhibited the phosphorylation of IRF5.

RT-PCR[1]

Cell Line: Mouse WT splenocytes
Concentration: 3 μM
Incubation Time: 30 min
Result: Induction of type I IFN genes, Ifnb1 and Ifna stimulated by TLR7 ligands or TLR9 ligands was remarkably weakened.
In Vivo

YE6144 (40.0 mg/kg; s.c.; once) free base suppresses the progression of mouse systemic lupus erythematosus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NZB/W F1 mouse model of systemic lupus erythematosus (SLE)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; once
Result: Suppressed the exacerbation of autoantibody production.
Splenomegaly and renal dysfunction were also suppressed by the treatment after disease onset.
Molecular Weight

411.48

Formula

C21H26FN7O
CAS No.
SMILES

CC[C@@H](CNC1=CC2=C(NN=C2/C=C/C3=CC=C(N4CCOCC4)N=N3)C=C1F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YE6144 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YE61443065657-01-1YE 6144YE-6144IFNARInterferon-α/β receptorInterferon-alpha/beta receptorhuman PBMCsmouse splenocytesNZB/W F1 mousesystemic lupus erythematosusInhibitorinhibitorinhibit

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