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Art. -Nr.: HY-150095A

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YE6144 free base

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research.

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CAS. Nr.: 3065657-01-1
Formel: C₂₁H₂₆FN₇O
Molecular Weight:411.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

YE6144 free base Chemical Structure

CAS. Nr.: 3065657-01-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IRF5

In Vitro

YE6144 (1 or 3 μM; 30 min) free base inhibits the phosphorylation of IRF5 in both human PBMCs and mouse splenocytes^[1].
YE6144 (0-10 μM; 30 min) free base inhibits the production of type I IFNs with an IC₅₀ of approximately 0.09 μM in human HC PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human HC PBMCs and mouse WT splenocytes
Concentration:

1 μM (PBMCs) and 3 μM (splenocytes)
Incubation Time:

30 min
Result:

Inhibited the phosphorylation of IRF5.

RT-PCR^[1]

Cell Line:

Mouse WT splenocytes
Concentration:

3 μM
Incubation Time:

30 min
Result:

Induction of type I IFN genes, Ifnb1 and Ifna stimulated by TLR7 ligands or TLR9 ligands was remarkably weakened.

In Vivo

YE6144 (40.0 mg/kg; s.c.; once) free base suppresses the progression of mouse systemic lupus erythematosus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NZB/W F1 mouse model of systemic lupus erythematosus (SLE)^[1]
Dosage:

40.0 mg/kg
Administration:

s.c.; once
Result:

Suppressed the exacerbation of autoantibody production.
Splenomegaly and renal dysfunction were also suppressed by the treatment after disease onset.

Chemical Information

CAS. Nr. 3065657-01-1
Molecular Weight 411.48
Formel C₂₁H₂₆FN₇O
SMILES

CC[C@@H](CNC1=CC2=C(NN=C2/C=C/C3=CC=C(N4CCOCC4)N=N3)C=C1F)N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

McGill University

2026.
bioRxiv

2024 August 19.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ban T, et al. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun. 2021 Jul 19;12(1):4379. [Content Brief]

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Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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YE6144 free base

2 Cited Publications

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
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YE6144 free base

Publications Citing Use of MedChemExpress (MCE) YE6144 free base

Biologische Aktivität

Chemical Information

Publications (2)

Reinheit & Dokumentation

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YE6144 free base Related Classifications

HY-150095A Related Classifications