country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-150095A

Copy Link Print Information

YE6144 free base

Name: YE6144 free base
Brand: MedChemExpress
SKU: HY-150095A
Availability: PreOrder

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research.

For research use only. We do not sell to patients.

CAS No.: 3065657-01-1
Formula: C₂₁H₂₆FN₇O
Molecular Weight:411.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

YE6144 free base Chemical Structure

CAS No.: 3065657-01-1

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IRF5

In Vitro

YE6144 (1 or 3 μM; 30 min) free base inhibits the phosphorylation of IRF5 in both human PBMCs and mouse splenocytes^[1].
YE6144 (0-10 μM; 30 min) free base inhibits the production of type I IFNs with an IC₅₀ of approximately 0.09 μM in human HC PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human HC PBMCs and mouse WT splenocytes
Concentration:

1 μM (PBMCs) and 3 μM (splenocytes)
Incubation Time:

30 min
Result:

Inhibited the phosphorylation of IRF5.

RT-PCR^[1]

Cell Line:

Mouse WT splenocytes
Concentration:

3 μM
Incubation Time:

30 min
Result:

Induction of type I IFN genes, Ifnb1 and Ifna stimulated by TLR7 ligands or TLR9 ligands was remarkably weakened.

In Vivo

YE6144 (40.0 mg/kg; s.c.; once) free base suppresses the progression of mouse systemic lupus erythematosus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NZB/W F1 mouse model of systemic lupus erythematosus (SLE)^[1]
Dosage:

40.0 mg/kg
Administration:

s.c.; once
Result:

Suppressed the exacerbation of autoantibody production.
Splenomegaly and renal dysfunction were also suppressed by the treatment after disease onset.

Chemical Information

CAS No. 3065657-01-1
Molecular Weight 411.48
Formula C₂₁H₂₆FN₇O
SMILES

CC[C@@H](CNC1=CC2=C(NN=C2/C=C/C3=CC=C(N4CCOCC4)N=N3)C=C1F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All

Sort by:

Journal Impact Factor

McGill University

2026.
bioRxiv

2024 August 19.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ban T, et al. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun. 2021 Jul 19;12(1):4379. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

YE6144 free base

2 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

YE6144 free base

Publications Citing Use of MedChemExpress (MCE) YE6144 free base

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

YE6144 free base Related Classifications

HY-150095A Related Classifications

Bioz