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Cat. No.: HY-146082

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(Z)-α-Cyanostilbene

(Z)-α-Cyanostilbene (compound 8), a dicyano substituted acrylonitrile, shows selective antiproliferative activity against HeLa and HepG2 cells, with IC₅₀s of 0.33 and 0.52 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 6114-57-4
Formula: C₁₅H₁₁N
Molecular Weight:205.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(Z)-α-Cyanostilbene Chemical Structure

CAS No.: 6114-57-4

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

(Z)-α-Cyanostilbene (compound 8), a dicyano substituted acrylonitrile, shows selective antiproliferative activity against HeLa and HepG2 cells, with IC₅₀s of 0.33 and 0.52 μM, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	64.6 μM Compound: 7	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31734024]
CFPAC-1	IC₅₀	88.19 μM Compound: 7	Antiproliferative activity against human CFPAC-1 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human CFPAC-1 cells incubated for 72 hrs by MTT assay	[PMID: 31734024]
HeLa	IC₅₀	48.88 μM Compound: 7	Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 31734024]
HepG2	IC₅₀	81.51 μM Compound: 7	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 31734024]
HFF	IC₅₀	93.73 μM Compound: 7	Cytotoxicity against HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31734024]
SW-620	IC₅₀	>100 μM Compound: 7	Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay	[PMID: 31734024]

Chemical Information

CAS No. 6114-57-4
Molecular Weight 205.25
Formula C₁₅H₁₁N
SMILES

N#C/C(C1=CC=CC=C1)=C\C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Perin N, et, al. Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1-b]thiophene derivatives. Eur J Med Chem. 2020 Jan 1;185:111833. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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