1. Epigenetics
    Anti-infection
  2. DNA Methyltransferase
    Virus Protease
  3. ZIKV-IN-3

ZIKV-IN-3 

Cat. No.: HY-151446
Handling Instructions

ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).

For research use only. We do not sell to patients.

ZIKV-IN-3 Chemical Structure

ZIKV-IN-3 Chemical Structure

CAS No. : 947699-46-9

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Description

ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV)[1].

IC50 & Target

IC50: 18.34 μM (MTase)[1]

In Vitro

ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC50 value of 0.76 μM and has anti-ZIKV effect with EC50 values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively[1].
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC50 value of 0.38 μM and inhibits ZIKV replication and infection[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells[1]. Vero, Huh7 and A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Vero, Huh7 and A549 cells
Concentration: 0.08, 0.4, 2, 10, and 50 μM
Incubation Time: 96 hours
Result: Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC50>200 μM to all three cell lines.

Western Blot Analysis[1]

Cell Line: Vero cells
Concentration: 0.08, 0.4, 2, 10, and 50 μM
Incubation Time: 48 hours
Result: Inhibited the expression of ZIKV E protein in a dose-dependent manner.
Molecular Weight

587.75

Formula

C39H41NO4

CAS No.
SMILES

O=C1OCC=C1/C=C/[[email protected]@H]2C(CC[[email protected]]3([H])[[email protected]@](COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)(C)/C(CC[[email protected]@]23C)=N/O)=C

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ZIKV-IN-3
Cat. No.:
HY-151446
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