2. PI3K/Akt/mTOR
  3. PIN1
  4. ZL-Pin01

ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM.

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ZL-Pin01

ZL-Pin01 화학구조

CAS No. : 1047464-92-5

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ZL-Pin01 Related Antibodies

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제품 설명

ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM[1].

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
12.8 μM
Compound: ZL-Pin01; DC-405
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 35089030]
MDA-MB-468 IC50
8.6 μM
Compound: ZL-Pin01; DC-405
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 35089030]
분자량

328.81

화학식

C14H17ClN2O3S
CAS No.
SMILES

O=C1CSC2(CCN(C(CCl)=O)CC2)N1CC3=CC=CO3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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ZL-Pin01 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZL-Pin011047464-92-5PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1covalentPin1 substrateinteractionInhibitorinhibitorinhibit

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상품명:
ZL-Pin01
Cat. No.:
HY-143902
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