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Cat. No.: HY-143902

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ZL-Pin01

ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC₅₀ of 1.33 μM.

For research use only. We do not sell to patients.

CAS No.: 1047464-92-5
Formula: C₁₄H₁₇ClN₂O₃S
Molecular Weight:328.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ZL-Pin01 Chemical Structure

CAS No.: 1047464-92-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	12.8 μM Compound: ZL-Pin01; DC-405	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay	[PMID: 35089030]
MDA-MB-468	IC₅₀	8.6 μM Compound: ZL-Pin01; DC-405	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay	[PMID: 35089030]

Chemical Information

CAS No. 1047464-92-5
Molecular Weight 328.81
Formula C₁₄H₁₇ClN₂O₃S
SMILES

O=C1CSC2(CCN(C(CCl)=O)CC2)N1CC3=CC=CO3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J Med Chem. 2022;65(3):2174-2190. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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