β-Nicotinamide adenine dinucleotide reduced dipotassium
Based on 11 publication(s) in Google Scholar
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally effective reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. β-Nicotinamide adenine dinucleotide reduced dipotassium regulates calcium homeostasis by promoting the opening of IP3-gated Ca2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. β-Nicotinamide adenine dinucleotide reduced dipotassium is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction.
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- CAS No.: 104809-32-7
- Formula: C21H27K2N7O14P2
- Molecular Weight:741.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) β-Nicotinamide adenine dinucleotide reduced dipotassium
More- Cell Mol Immunol. 2024 Jun;21(6):561-574. [Abstract]
- Food Chem. 2023 Oct 15:423:136274. [Abstract]
- Biomater Res. 2026 Apr 29.
- Free Radic Biol Med. 2025 Jan:226:56-69. [Abstract]
- J Ginseng Res. 2025 Sep;49(5):541-552. [Abstract]
- Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]
- Microorganisms. 2026 May 9;14(5):1070. [Abstract]
- ACS Chem Biol. 2026 Jul 2.
- Biochemistry. 2023 Dec 5;62(23):3396-3410. [Abstract]
- Chemrxiv. 2025 Aug 28.
- Research Square Preprint. 2023 Sep 15.
All Endogenous Metabolite Isoforms
MoreAll Calcium Channel Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Calcium Channel |
In Vitro
β-Nicotinamide adenine dinucleotide reduced dipotassium (5 mM; 1-20 min) decreases Na+ binding capacity in purified V-ATPase, with Kd values of 20 µM and 15 µM in the presence and absence of ATP (HY-B2176), respectively[3].
β-Nicotinamide adenine dinucleotide reduced (10 µM - 10 mM) dipotassium inhibits PARP-1 (HY-P73337)-mediated cell death and increases intracellular NAD+ levels in mouse astrocytes and can be transported into cells via P2X7 receptor-mediated uptake[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat model of 2-hour transient focal ischemia[1]
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Dosage:10, 20 mg/kg
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Administration:intranasal administration; single dose; given 2 hours after ischemic onset
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Result:Significantly reduced the formation of brain infarction.
Improved neurological deficits by more than 80%.
Chemical Information
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CAS No. 104809-32-7
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Molecular Weight 741.62
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Formula C21H27K2N7O14P2
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SMILES
O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@](N3C=C(CC=C3)C(N)=O)([H])[C@@H]([C@@H]2O)O)(O[K])=O)(O[K])=O)([H])N4C5=NC=NC(N)=C5N=C4
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (11)
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Journal Impact Factor
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Most Recent
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Cell Mol Immunol
2024 Jun;21(6):561-574. PMID: 38570588 -
Food Chem
Improvement of catalytic activity of sorbose dehydrogenase for deoxynivalenol degradation by rational design. [Abstract]2023 Oct 15:423:136274. PMID: 37159968 -
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Free Radic Biol Med
TSPO exacerbates sepsis-induced cardiac dysfunction by inhibiting p62-Mediated autophagic flux via the ROS-RIP1/RIP3-exosome axis. [Abstract]2025 Jan:226:56-69. PMID: 39542185 -
J Ginseng Res
Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD+ metabolism and promoting IDO2/QPRT expression. [Abstract]2025 Sep;49(5):541-552. PMID: 40843012 -
Mol Plant Pathol
Negative Immune Regulator CAD7 Functions as a Small-Molecule Aldehyde Reductase and Increases Histamine Accumulation in Arabidopsis. [Abstract]2025 Dec;26(12):e70196. PMID: 41456913 -
Microorganisms
Characterization of RmlABCD Enzymes from Marine Bacteria and Efficient Synthesis of dTDP-L-Rhamnose. [Abstract]2026 May 9;14(5):1070. PMID: 42197457 -
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Biochemistry
Full-Length NAD+-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate. [Abstract]2023 Dec 5;62(23):3396-3410. PMID: 37947391 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Nicotinamide adenine dinucleotide reduced dipotassium Related Classifications
HY-W250154 Related Classifications
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Keywords
- β-Nicotinamide adenine dinucleotide reduced dipotassium
- 104809-32-7
- Endogenous Metabolite
- Calcium Channel
- VDAC
- xanthine oxidase
- astrocyte death
- VDAC inhibitor
- IP3-gated channels
- PARP-1
- cerebral ischemia
- mitochondrial permeability transition
- NAD(P)H oxidase
- cardiac ryanodine receptors
- P2X7 receptors
- Inhibitor
- inhibitor
- inhibit