104809-32-7
Chemical Structure
β-Nicotinamide adenine dinucleotide reduced dipotassium
- CAS No.: 104809-32-7
- Formula:C21H27K2N7O14P2
- Molecular Weight:741.62
InChIKey: UMJWDCRRGAZCFU-WUEGHLCSSA-L
SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@](N3C=C(CC=C3)C(N)=O)([H])[C@@H]([C@@H]2O)O)(O[K])=O)(O[K])=O)([H])N4C5=NC=NC(N)=C5N=C4
Biological Activity: β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally effective reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. β-Nicotinamide adenine dinucleotide reduced dipotassium regulates calcium homeostasis by promoting the opening of IP3-gated Ca2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. β-Nicotinamide adenine dinucleotide reduced dipotassium is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction[1][2][3].
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β-Nicotinamide adenine dinucleotide reduced dipotassium | β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally effective reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. β-Nicotinamide adenine dinucleotide reduced dipotassium regulates calcium homeostasis by promoting the opening of IP3-gated Ca2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. β-Nicotinamide adenine dinucleotide reduced dipotassium is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction. | |||||||||||||||||||||
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References
- [1]. Ying W. NAD+ and NADH in cellular functions and cell death. Front Biosci. 2006 Sep 1;11:3129-48. [Content Brief]
- [2]. Nagababu E, et al. Assessment of antioxidant activity of eugenol in vitro and in vivo. Methods Mol Biol. 2010;610:165-80.
- [3]. Murata T, et al. ATP-dependent affinity change of Na+-binding sites of V-ATPase. The Journal of biological chemistry. 2001 Dec 21;276(51):48337-40.
