1αH,5αH-Guaia-6-ene-4β,10β-diol
Based on 1 Customer Validation
1αH,5αH-Guaia-6-ene-4β,10β-diol is a sesquiterpenoid derivative identified from Alisma orientale. 1αH,5αH-Guaia-6-ene-4β,10β-diol has anti-cancer activities.
For research use only. We do not sell to patients.
- Purity : 96.72%
- CAS No.: 2013537-81-8
- Formula: C15H26O2
- Molecular Weight:238.37
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
1αH,5αH-Guaia-6-ene-4β,10β-diol has anti-cancer activities. 1αH,5αH-Guaia-6-ene-4β,10β-diol is against H460, MCF-7, and PC-7 with IC50s of 56.7 μM, 76.7 μM, and 59.0 μM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2013537-81-8
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Appearance Solid
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Molecular Weight 238.37
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Formula C15H26O2
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Color White to off-white
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SMILES
O[C@@]1(C)CC[C@@]2([H])[C@](O)(C)CCC(C(C)C)=C[C@@]12[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (209.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1952 mL | 20.9758 mL | 41.9516 mL | 104.8790 mL |
| 5 mM | 0.8390 mL | 4.1952 mL | 8.3903 mL | 20.9758 mL | |
| 10 mM | 0.4195 mL | 2.0976 mL | 4.1952 mL | 10.4879 mL | |
| 15 mM | 0.2797 mL | 1.3984 mL | 2.7968 mL | 6.9919 mL | |
| 20 mM | 0.2098 mL | 1.0488 mL | 2.0976 mL | 5.2439 mL | |
| 25 mM | 0.1678 mL | 0.8390 mL | 1.6781 mL | 4.1952 mL | |
| 30 mM | 0.1398 mL | 0.6992 mL | 1.3984 mL | 3.4960 mL | |
| 40 mM | 0.1049 mL | 0.5244 mL | 1.0488 mL | 2.6220 mL | |
| 50 mM | 0.0839 mL | 0.4195 mL | 0.8390 mL | 2.0976 mL | |
| 60 mM | 0.0699 mL | 0.3496 mL | 0.6992 mL | 1.7480 mL | |
| 80 mM | 0.0524 mL | 0.2622 mL | 0.5244 mL | 1.3110 mL | |
| 100 mM | 0.0420 mL | 0.2098 mL | 0.4195 mL | 1.0488 mL |
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