2′,3′-Dideoxy-3′-fluorouridine
2′,3′-Dideoxy-3′-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 41107-56-6
- Formula: C9H11FN2O4
- Molecular Weight:230.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L6 | IC50 |
>391 μM
Compound: 4d
|
In vitro cytotoxicity aganist rat skeletal myoblasts (L-6 cells) after 72 hours
In vitro cytotoxicity aganist rat skeletal myoblasts (L-6 cells) after 72 hours
|
[PMID: 16161998] |
| MT4 | ED50 |
0.04 μM
Compound: 3c
|
Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells.
Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells.
|
[PMID: 3172142] |
| MT4 | ED50 |
0.04 μM
Compound: FddUrd
|
Inhibitory activity against HIV-1 replication in MT-4 cells
Inhibitory activity against HIV-1 replication in MT-4 cells
|
[PMID: 2754700] |
Chemical Information
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CAS No. 41107-56-6
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Molecular Weight 230.19
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Formula C9H11FN2O4
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SMILES
OC[C@@H]1[C@@H](F)C[C@H](N2C(NC(C=C2)=O)=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)