DL-Homocysteine
Based on 4 publication(s) in Google Scholar
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity.
For research use only. We do not sell to patients.
- Purity: 99.32%
- CAS No.: 454-29-5
- Formula: C4H9NO2S
- Molecular Weight:135.19
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W010347
L-Homocysteine
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HY-100558
Bafilomycin A1
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HY-W040821R
DL-Homocysteine (Standard)
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HY-N0229
L-Alanine
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HY-N0304
L-DOPA
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HY-N0391
L-Citrulline
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HY-Y0337
L-Cysteine
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HY-N0230
β-Alanine
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HY-N0394
L-Cystine
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HY-16714
4-Azido-L-phenylalanine
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HY-N0067
γ-Aminobutyric acid
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HY-N0455A
L-Arginine hydrochloride
Publications Citing Use of MedChemExpress (MCE) DL-Homocysteine
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 454-29-5
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Appearance Solid
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Molecular Weight 135.19
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Formula C4H9NO2S
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Color White to off-white
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SMILES
O=C(O)C(N)CCS
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Redox Biol
ATF7IP inhibits Sorafenib-induced ferroptosis in hepatocellular carcinoma cells by inhibiting CYB5R2 transcription and stabilizing PARK7 protein. [Abstract]2025 Sep:85:103786. PMID: 40716153 -
Eur J Neurosci
Homocysteine-potentiated Kelch-like ECH-associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β-catenin. [Abstract]2024 May;59(10):2732-2747. PMID: 38501537 -
Medicine (Baltimore)
Elevated homocysteine contributes to the progression of type 1 diabetic nephropathy: Evidence from Mendelian randomization and experimental validation. [Abstract]2026 Jan 30;105(5):e47341. PMID: 41630263 -
Solvent & Solubility
H2O : 100 mg/mL (739.71 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (622 KB)
- English - EN (622 KB)
- Français - FR (622 KB)
- Deutsch - DE (622 KB)
- Norwegian - NO (622 KB)
- Español - ES (622 KB)
- Swedish - SV (622 KB)
- Italian - IT (622 KB)
- Korean - KR (622 KB)
- Portuguese - PT (622 KB)
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Handling Instructions (2659 KB)
References
[1]. DL-Homocysteine, et al. Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid. J Neurosci Res. 2005 Feb 1;79(3):375-82. [Content Brief]
[2]. Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.3971 mL | 36.9855 mL | 73.9711 mL | 184.9277 mL |
| 5 mM | 1.4794 mL | 7.3971 mL | 14.7942 mL | 36.9855 mL | |
| 10 mM | 0.7397 mL | 3.6986 mL | 7.3971 mL | 18.4928 mL | |
| 15 mM | 0.4931 mL | 2.4657 mL | 4.9314 mL | 12.3285 mL | |
| 20 mM | 0.3699 mL | 1.8493 mL | 3.6986 mL | 9.2464 mL | |
| 25 mM | 0.2959 mL | 1.4794 mL | 2.9588 mL | 7.3971 mL | |
| 30 mM | 0.2466 mL | 1.2329 mL | 2.4657 mL | 6.1643 mL | |
| 40 mM | 0.1849 mL | 0.9246 mL | 1.8493 mL | 4.6232 mL | |
| 50 mM | 0.1479 mL | 0.7397 mL | 1.4794 mL | 3.6986 mL | |
| 60 mM | 0.1233 mL | 0.6164 mL | 1.2329 mL | 3.0821 mL | |
| 80 mM | 0.0925 mL | 0.4623 mL | 0.9246 mL | 2.3116 mL | |
| 100 mM | 0.0740 mL | 0.3699 mL | 0.7397 mL | 1.8493 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DL-Homocysteine Related Classifications
HY-W040821 Related Classifications
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