1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

DL-Homocysteine 

Cat. No.: HY-W040821
Handling Instructions

DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.

For research use only. We do not sell to patients.

DL-Homocysteine Chemical Structure

DL-Homocysteine Chemical Structure

CAS No. : 454-29-5

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM[1].

In Vivo

DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3970 mL 36.9850 mL 73.9700 mL
5 mM 1.4794 mL 7.3970 mL 14.7940 mL
10 mM 0.7397 mL 3.6985 mL 7.3970 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

135.19

Formula

C₄H₉NO₂S

CAS No.

454-29-5

SMILES

O=C(O)C(N)CCS

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
DL-Homocysteine
Cat. No.:
HY-W040821
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DL-Homocysteine

Cat. No.: HY-W040821