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Cat. No.: HY-113252R

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2-Methoxyestrone (Standard)

2-Methoxyestrone (Standard) is the analytical standard of 2-Methoxyestrone (HY-113252). This product is intended for research and analytical applications. 2-Methoxyestrone is an estrogen metabolite with antimitotic activity. 2-Methoxyestrone acts as a liver-specific prohormone that undergoes demethylation to form active 2-hydroxyestrogens, and it can also interconvert with 2-Methoxyestradiol (HY-12033) via the 17β-hydroxysteroid dehydrogenase pathway. In the presence of all-trans retinoic acid, 2-Methoxyestrone exerts a strong, concentration-dependent inhibitory effect on cell growth. 2-Methoxyestrone delays the progression of pulmonary hypertension in rats, alleviates right ventricular and pulmonary vascular remodeling, and relieves proliferative pulmonary hypertension in rats. 2-Methoxyestrone can be used in studies related to proliferative pulmonary hypertension.

For research use only. We do not sell to patients.

CAS No.: 362-08-3
Formula: C₁₉H₂₄O₃
Molecular Weight:300.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Methoxyestrone (Standard) Chemical Structure

CAS No.: 362-08-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-113252
2-Methoxyestrone

Estrogen Metabolite

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- Application
Chemical Information
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 362-08-3
Molecular Weight 300.39
Formula C₁₉H₂₄O₃
SMILES

C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=C(OC)C(O)=C4)[C@@]3([H])CC1)C2=O
Structure Classification
- Phenols
- Monophenols
- Steroids
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Hu J, et al. Abstract 18888: 2‑Methoxyestrone Retards the Progression of Angioproliferative Pulmonary Hypertension in Rats‑Role of 17beta‑Hydroxysteroid Dehydrogenase Pathway. Circulation, 2015, 132(Suppl 3):A18888.

[2]. Martucci CP, et al. The role of 2-methoxyestrone in estrogen action. Journal of steroid biochemistry. 1983 Jul;19(1B):635-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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