(2S,3R,4S)-4-Hydroxyisoleucine
Based on 1 Customer Validation
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S)-4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S)-4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 55399-93-4
- Formula: C6H13NO3
- Molecular Weight:147.17
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Protein Tyrosine Kinase Compound Library
HY-L016
-
Natural Product Library
HY-L021
-
Clinical Compound Library
HY-L026
-
Anti-Aging Compound Library
HY-L034
-
Drug Repurposing Compound Library
HY-L035
-
Anti-diabetic Compound Library
HY-L040
-
Orally Active Compound Library
HY-L061
-
Traditional Chinese Medicine Active Compound Library
HY-L065
-
Plant-Sourced Natural Product Library
HY-L115
-
Metabolic Enzyme Compound Library
HY-L146
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Protein Kinase Compound Library
HY-L196
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
-
Mongolian Medicine Compound Library
HY-L238
-
Natural Product Diversity Scaffold Library
HY-L245
-
Tonifying Traditional Chinese Medicine Monomer Compound Library
HY-L246
-
Mass Spectrometry Natural Product Library
HY-L262
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Streptozotocin (HY-13753)-induced type I diabetic rats[3]
-
Dosage:50 mg/kg
-
Administration:intubated, daily, 4 weeks
-
Result:Induced a reduction in blood glucose from 500 mg/dl to 330 mg/dl.
Restored the diabetic lipid profile to an almost normal one.
Reversed the changes in HDL induced by Streptozotocin.
Reduced the increased hyperuricemia.
Chemical Information
-
CAS No. 55399-93-4
-
Appearance Solid
-
Molecular Weight 147.17
-
Formula C6H13NO3
-
Color White to off-white
-
SMILES
O[C@@H](C)[C@H](C)[C@H](N)C(O)=O
-
Synonyms
(2S,3R,4S)-4-Hydroxy-L-isoleucine
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (339.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Shi X, et al. Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers. Sci Rep. 2017 Oct 20;7(1):13703. [Content Brief]
[2]. Broca C, et al. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. Eur J Pharmacol. 2000 Mar 3;390(3):339-45. [Content Brief]
[3]. Haeri MR, et al. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine. 2012 May 15;19(7):571-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7949 mL | 33.9743 mL | 67.9486 mL | 169.8716 mL |
| 5 mM | 1.3590 mL | 6.7949 mL | 13.5897 mL | 33.9743 mL | |
| 10 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL | 16.9872 mL | |
| 15 mM | 0.4530 mL | 2.2650 mL | 4.5299 mL | 11.3248 mL | |
| 20 mM | 0.3397 mL | 1.6987 mL | 3.3974 mL | 8.4936 mL | |
| 25 mM | 0.2718 mL | 1.3590 mL | 2.7179 mL | 6.7949 mL | |
| 30 mM | 0.2265 mL | 1.1325 mL | 2.2650 mL | 5.6624 mL | |
| 40 mM | 0.1699 mL | 0.8494 mL | 1.6987 mL | 4.2468 mL | |
| 50 mM | 0.1359 mL | 0.6795 mL | 1.3590 mL | 3.3974 mL | |
| 60 mM | 0.1132 mL | 0.5662 mL | 1.1325 mL | 2.8312 mL | |
| 80 mM | 0.0849 mL | 0.4247 mL | 0.8494 mL | 2.1234 mL | |
| 100 mM | 0.0679 mL | 0.3397 mL | 0.6795 mL | 1.6987 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(2S,3R,4S)-4-Hydroxyisoleucine Related Classifications
HY-W010271 Related Classifications
Powered by Bioz