1. Antibody-Drug Conjugate/ADC Related
  2. ADC Linkers
  3. 3,4-Dibromo-Mal-PEG4-Acid

3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

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3,4-Dibromo-Mal-PEG4-Acid

3,4-Dibromo-Mal-PEG4-Acid 화학구조

CAS No. : 2434639-17-3

사이즈 가격 재고 수량
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 견적 받기
1 g   견적 받기  
5 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

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제품 설명

3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

분자량

503.14

화학식

C15H21Br2NO8

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCOCCOCCOCCOCCN1C(C(Br)=C(C1=O)Br)=O)O

선적

Room temperature in continental US; may vary elsewhere.

보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (198.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9875 mL 9.9376 mL 19.8752 mL
5 mM 0.3975 mL 1.9875 mL 3.9750 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.36%

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9875 mL 9.9376 mL 19.8752 mL 49.6880 mL
5 mM 0.3975 mL 1.9875 mL 3.9750 mL 9.9376 mL
10 mM 0.1988 mL 0.9938 mL 1.9875 mL 4.9688 mL
15 mM 0.1325 mL 0.6625 mL 1.3250 mL 3.3125 mL
20 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4844 mL
25 mM 0.0795 mL 0.3975 mL 0.7950 mL 1.9875 mL
30 mM 0.0663 mL 0.3313 mL 0.6625 mL 1.6563 mL
40 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2422 mL
50 mM 0.0398 mL 0.1988 mL 0.3975 mL 0.9938 mL
60 mM 0.0331 mL 0.1656 mL 0.3313 mL 0.8281 mL
80 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.6211 mL
100 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4969 mL
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상품명:
3,4-Dibromo-Mal-PEG4-Acid
Cat. No.:
HY-W591402
수량:
MCE Japan Authorized Agent: