3′-Chloro-3′-deoxythymidine
3′-Chloro-3′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 25526-94-7
- Formula: C10H13ClN2O4
- Molecular Weight:260.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | EC50 |
10 μg/mL
Compound: 17
|
Antiviral activity against DHBV infected in duck hepatocytes assessed as inhibition of viral DNA replication after 2 days
Antiviral activity against DHBV infected in duck hepatocytes assessed as inhibition of viral DNA replication after 2 days
|
[PMID: 20869253] |
| HepG2 2.2.15 | EC50 |
10 μg/mL
Compound: 17
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 2 days
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 2 days
|
[PMID: 20869253] |
| Huh-7 | CC50 |
>100 μg/mL
Compound: 8
|
Cytotoxicity against human HuH7 cells after 2 days by XTT assay
Cytotoxicity against human HuH7 cells after 2 days by XTT assay
|
[PMID: 20420370] |
| Huh-7 | CC50 |
>100 μg/mL
Compound: 8
|
Cytotoxicity against human HuH7 cells assessed as incorporation of [3H]thymidine into DNA after 2 days by scintillation counting
Cytotoxicity against human HuH7 cells assessed as incorporation of [3H]thymidine into DNA after 2 days by scintillation counting
|
[PMID: 20420370] |
| Huh-7 | CC50 |
>200 μg/mL
Compound: 17
|
Cytotoxicity against human HuH7 cells after 2 days by XTT assay
Cytotoxicity against human HuH7 cells after 2 days by XTT assay
|
[PMID: 20869253] |
Chemical Information
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CAS No. 25526-94-7
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Molecular Weight 260.67
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Formula C10H13ClN2O4
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SMILES
Cl[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)