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Cat. No.: HY-W728151

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3-O-Caffeoylshikimic acid

Name: 3-O-Caffeoylshikimic acid
Brand: MedChemExpress
SKU: HY-W728151
Price: 200.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

3-O-Caffeoylshikimic acid is a caffeoylshikimic acid substance and phenolic acid that widely exists in the aerial parts of Equisetum arvense L. and Smilax glabra. During sulfur fumigation processing, 3-O-Caffeoylshikimic acid undergoes chemical transformation to produce 3-O-caffeoylshikimic acid sulfate and 3-O-caffeoylshikimic acid sulfite. At a high concentration (40 μM), 3-O-Caffeoylshikimic acid exhibits cytotoxic activity against human keratinocytes.

For research use only. We do not sell to patients.

Purity: 70.0%
CAS No.: 180981-12-8
Formula: C₁₆H₁₆O₈
Molecular Weight:336.29

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

3-O-Caffeoylshikimic acid Chemical Structure

CAS No.: 180981-12-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

3-O-Caffeoylshikimic acid (compound 9)(40-80 μM; 24 h) is non-cytotoxic to HaCaT human keratinocytes at 40 μM, exhibits cytotoxicity at 80 μM, and does not significantly improve TNFα/IFNγ-induced cell viability reduction at 40 μM^[1].
3-O-Caffeoylshikimic acid (40 μM; 2 h pre-treatment, followed by 10 min TNFα/IFNγ stimulation) does not significantly inhibit activation of NF-κB, AP-1 (c-Jun), or STAT1 pro-inflammatory transcription factors in TNFα/IFNγ-stimulated HaCaT human keratinocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HaCaT human keratinocytes
Concentration:

40 μM, 80 μM (without TNFα/IFNγ stimulation); 40 μM (with TNFα/IFNγ stimulation)
Incubation Time:

24 h
Result:

Showed no cytotoxicity in HaCaT cells without TNFα/IFNγ stimulation at 40 μM.
Exhibited cytotoxicity in HaCaT cells without TNFα/IFNγ stimulation at 80 μM.
Did not significantly improve the TNFα/IFNγ-induced reduction in cell viability at 40 μM.

Chemical Information

CAS No. 180981-12-8
Appearance Solid
Molecular Weight 336.29
Formula C₁₆H₁₆O₈
Color White to off-white
SMILES

O=C(O[C@H]1[C@@H](O)[C@@H](CC(C(O)=O)=C1)O)/C=C/C2=CC(O)=C(C=C2)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeong S Y, et al. Phytochemical investigation of Equisetum arvense and evaluation of their anti-inflammatory potential in TNFα/INFγ-stimulated keratinocytes[J]. Pharmaceuticals, 2023, 16(10): 1478.

[2]. He L, et al. Rapid discrimination of raw and sulfur-fumigated Smilax glabra based on chemical profiles by UHPLC-QTOF-MS/MS coupled with multivariate statistical analysis[J]. Food Research International, 2018, 108: 226-236.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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