4-Chlorobutyronitrile
Based on 1 Customer Validation
4-Chlorobutyronitrile is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 98.00%
- CAS No.: 628-20-6
- Formula: C4H6ClN
- Molecular Weight:103.55
-
Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
-
Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E385 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 628-20-6
-
Appearance Liquid
-
Molecular Weight 103.55
-
Formula C4H6ClN
-
Color Colorless to light yellow
-
SMILES
N#CCCCCl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (965.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (239 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.6572 mL | 48.2859 mL | 96.5717 mL | 241.4293 mL |
| 5 mM | 1.9314 mL | 9.6572 mL | 19.3143 mL | 48.2859 mL | |
| 10 mM | 0.9657 mL | 4.8286 mL | 9.6572 mL | 24.1429 mL | |
| 15 mM | 0.6438 mL | 3.2191 mL | 6.4381 mL | 16.0953 mL | |
| 20 mM | 0.4829 mL | 2.4143 mL | 4.8286 mL | 12.0715 mL | |
| 25 mM | 0.3863 mL | 1.9314 mL | 3.8629 mL | 9.6572 mL | |
| 30 mM | 0.3219 mL | 1.6095 mL | 3.2191 mL | 8.0476 mL | |
| 40 mM | 0.2414 mL | 1.2071 mL | 2.4143 mL | 6.0357 mL | |
| 50 mM | 0.1931 mL | 0.9657 mL | 1.9314 mL | 4.8286 mL | |
| 60 mM | 0.1610 mL | 0.8048 mL | 1.6095 mL | 4.0238 mL | |
| 80 mM | 0.1207 mL | 0.6036 mL | 1.2071 mL | 3.0179 mL | |
| 100 mM | 0.0966 mL | 0.4829 mL | 0.9657 mL | 2.4143 mL |
4-Chlorobutyronitrile Related Classifications
HY-Y0259 Related Classifications
Powered by Bioz