4-(Trifluoromethoxy)aniline
Based on 1 Customer Validation
4-(Trifluoromethoxy) aniline is an intermediate. 4-(Trifluoromethoxy) aniline can be used for the synthesis of Compound 80. 4-(Trifluoromethoxy) aniline can be applied to AIDS research.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 461-82-5
- Formula: C7H6F3NO
- Molecular Weight:177.13
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
4-(Trifluoromethoxy) aniline serves as an intermediate in the synthesis research of Compound 80[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 461-82-5
-
Appearance Liquid (Density: 1.32 g/cm3)
-
Molecular Weight 177.13
-
Formula C7H6F3NO
-
Color Colorless to off-white
-
SMILES
FC(F)(OC1=CC=C(N)C=C1)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (564.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (806 KB)
- English - EN (806 KB)
- Français - FR (806 KB)
- Deutsch - DE (806 KB)
- Norwegian - NO (806 KB)
- Español - ES (806 KB)
- Swedish - SV (806 KB)
- Italian - IT (806 KB)
- Korean - KR (806 KB)
- Portuguese - PT (806 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6456 mL | 28.2279 mL | 56.4557 mL | 141.1393 mL |
| 5 mM | 1.1291 mL | 5.6456 mL | 11.2911 mL | 28.2279 mL | |
| 10 mM | 0.5646 mL | 2.8228 mL | 5.6456 mL | 14.1139 mL | |
| 15 mM | 0.3764 mL | 1.8819 mL | 3.7637 mL | 9.4093 mL | |
| 20 mM | 0.2823 mL | 1.4114 mL | 2.8228 mL | 7.0570 mL | |
| 25 mM | 0.2258 mL | 1.1291 mL | 2.2582 mL | 5.6456 mL | |
| 30 mM | 0.1882 mL | 0.9409 mL | 1.8819 mL | 4.7046 mL | |
| 40 mM | 0.1411 mL | 0.7057 mL | 1.4114 mL | 3.5285 mL | |
| 50 mM | 0.1129 mL | 0.5646 mL | 1.1291 mL | 2.8228 mL | |
| 60 mM | 0.0941 mL | 0.4705 mL | 0.9409 mL | 2.3523 mL | |
| 80 mM | 0.0706 mL | 0.3528 mL | 0.7057 mL | 1.7642 mL | |
| 100 mM | 0.0565 mL | 0.2823 mL | 0.5646 mL | 1.4114 mL |
4-(Trifluoromethoxy)aniline Related Classifications
HY-W016664 Related Classifications
Powered by Bioz