2. Immunology/Inflammation Cytoskeleton
  3. Interleukin Related Collagen
  4. 4L2-P13D

4L2-P13D is an IL-11 antagonist with an IC50 of 2.8 μM. 4L2-P13D has a KD of 11 nM for hIL-11. 4L2-P13D exhibits antifibrotic and renoprotective activities. 4L2-P13D can be used in the research of renal fibrosis.

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4L2-P13D

4L2-P13D Chemical Structure

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4L2-P13D Related Antibodies

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Description

4L2-P13D is an IL-11 antagonist with an IC50 of 2.8 μM. 4L2-P13D has a KD of 11 nM for hIL-11. 4L2-P13D exhibits antifibrotic and renoprotective activities. 4L2-P13D can be used in the research of renal fibrosis[1].

In Vitro

4L2-P13D (0.5-5 μM; 72 h) reduces the expression of profibrotic factors (FN1, COL1A1) in TGF-β1-induced HK-2 cells in a dose-dependent manner[1].
4L2-P13D (0-50 μM; 24 h) exhibits no cytotoxicity against HK-2 cells even at concentrations as high as 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4L2-P13D Related Antibodies

Western Blot Analysis[1]

Cell Line: TGF-β1-induced human proximal tubular epithelial (HK-2) cells
Concentration: 0.5, 2 and 5 μM
Incubation Time: 72 h
Result: Dose-dependently reduced fibronectin (FN1) and type I collagen (COL1A1) expression.
In Vivo

4L2-P13D (0.5-2 mg/kg; s.c.; daily administration; 7 days) exhibits potent anti-renal fibrosis activity in the UUO mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 6-8 weeks old, UUO model)[1]
Dosage: 0.5 mg/kg; 2 mg/kg
Administration: s.c.; daily; 7 days
Result: Significantly reduced expression levels of fibrosis markers FN1 and α-smooth muscle α-SMA.
Remarkably reduced proinflammatory markers (TNF-α, TGF-β1, IL-6, IL-1β) and kidney injury markers (Kim1, Ngal).
Reduced blood urea nitrogen (BUN) and creatinine levels.
Significantly improved collagen deposition, with the high-dose group showing superior efficacy compared to the low-dose group.
Molecular Weight

1859.11

Formula

C89H123N19O23S
Sequence

Ac-Tyr-Leu-Ile-Gln-His-Tyr-Tyr-Thr-Phe-Ile-Ala-Leu-Asp-Cys-Gly-NH2 (sulfide bridge: Tyr1-Cys14)
Sequence Shortening

Ac-YLIQHYYTFIALDCG-NH2 (sulfide bridge: Tyr1-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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4L2-P13D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4L2-P13DInterleukin RelatedCollagenILrenal epithelial cellsHK-2 cellsunilateral ureteral obstruction mouse modelsInhibitorinhibitorinhibit

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