5,15-Diphenylporphyrin
Based on 1 Customer Validation
5,15-Diphenylporphyrin (5,15-DPP) is an inhibitor of the oncogenic transcription factor STAT3. 5,15-Diphenylporphyrin specifically binds to the SH2 domain of STAT3, blocking the pTyr-SH2 interaction, thereby inhibiting the dimerization, nuclear translocation and DNA binding activity of STAT3, and ultimately inhibiting the expression of cancer cell-related genes. 5,15-Diphenylporphyrin can be used in research fields related to the development of anticancer drugs
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 22112-89-6
- Formula: C32H22N4
- Molecular Weight:462.54
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
2.63 ng/mL
Compound: 8
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Cytotoxicity against human HCT116 cell line
Cytotoxicity against human HCT116 cell line
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[PMID: 16722648] |
| HCT-116 | IC50 |
5.66 nM
Compound: 8
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Cytotoxicity against human HCT116 cell line
Cytotoxicity against human HCT116 cell line
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[PMID: 16722648] |
| HCT-116 | IC50 |
5.66 nM
Compound: 3
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Phototoxicity against human HCT116 cells after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by MTT assay
Phototoxicity against human HCT116 cells after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by MTT assay
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[PMID: 19211252] |
| Peritoneal macrophage | CC50 |
>100 μM
Compound: 4a
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Cytotoxicity against Swiss mouse peritoneal macrophages at 20 uM after 5 days by MTT assay
Cytotoxicity against Swiss mouse peritoneal macrophages at 20 uM after 5 days by MTT assay
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[PMID: 23851117] |
5,15-Diphenylporphyrin (50 μM; 24 h) inhibits STAT3 dimerization, nuclear translocation, DNA binding activity, c-myc promoter binding, and c-myc protein expression in MDA-MB-468 cells and HEK293 cells, and is selective for STAT3 over STAT1 and Grb2 in an AlphaScreen-based assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 22112-89-6
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Appearance Solid
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Molecular Weight 462.54
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Formula C32H22N4
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Color Brown to black
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SMILES
C1(/C2=CC=CC=C2)=C3C=CC(/C=C4C=C/C(N/4)=C(C5=CC=CC=C5)/C(C=C/6)=NC6=C/C7=CC=C1N7)=N/3
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Synonyms
5,15-DPP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMF : 5 mg/mL (10.81 mM; ultrasonic and warming and heat to 60°C)
DMSO : 2 mg/mL (4.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 2.1620 mL | 10.8099 mL | 21.6198 mL | 54.0494 mL |
| DMF | 5 mM | 0.4324 mL | 2.1620 mL | 4.3240 mL | 10.8099 mL |
| 10 mM | 0.2162 mL | 1.0810 mL | 2.1620 mL | 5.4049 mL |
5,15-Diphenylporphyrin Related Classifications
HY-W035137 Related Classifications
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