5,15-Diphenylporphyrin  (Synonyms: 5,15-DPP)

5,15-Diphenylporphyrin (5,15-DPP) is an inhibitor of the oncogenic transcription factor STAT3. 5,15-Diphenylporphyrin specifically binds to the SH2 domain of STAT3, blocking the pTyr-SH2 interaction, thereby inhibiting the dimerization, nuclear translocation and DNA binding activity of STAT3, and ultimately inhibiting the expression of cancer cell-related genes. 5,15-Diphenylporphyrin can be used in research fields related to the development of anticancer drugs[1][2].

5,15-Diphenylporphyrin (50 μM; 24 h) inhibits STAT3 dimerization, nuclear translocation, DNA binding activity, c-myc promoter binding, and c-myc protein expression in MDA-MB-468 cells and HEK293 cells, and is selective for STAT3 over STAT1 and Grb2 in an AlphaScreen-based assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

462.54

C₃₂H₂₂N₄

22112-89-6

Solid

Brown to black

C1(/C2=CC=CC=C2)=C3C=CC(/C=C4C=C/C(N/4)=C(C5=CC=CC=C5)/C(C=C/6)=NC6=C/C7=CC=C1N7)=N/3

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Uehara Y, et al. Novel high-throughput screening system for identifying STAT3-SH2 antagonists. Biochem Biophys Res Commun. 2009;380(3):627-631.  [Content Brief]

  [2]. Xiang F, et al. Coverage-induced chiral transition of Co (II)-5, 15-diphenylporphyrin self-assemblies on Cu (111)[J]. The Journal of Physical Chemistry C, 2022, 126(15): 6745-6752.