5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone
5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone (compound 1), a flavonoid, is a potent ABCG2 inhibitor with an IC50 of 6.6 μM.
For research use only. We do not sell to patients.
- CAS No.: 1268140-15-3
- Formula: C21H22O6
- Molecular Weight:370.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H460 | IC50 |
6.6 μM
Compound: 1
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Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C
Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C
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[PMID: 21275386] |
Chemical Information
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CAS No. 1268140-15-3
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Molecular Weight 370.40
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Formula C21H22O6
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SMILES
O=C1C2=C(O)C=C(O)C(C/C=C(C)\C)=C2O[C@H](C3=CC(O)=C(C=C3)OC)C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone Related Classifications
HY-N2651 Related Classifications
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