1. Immunology/Inflammation
  2. Glucocorticoid Receptor
  3. Mizacorat

Mizacorat  (Synonyms: AZD9567)

製品番号: HY-120012 純度: 99.71%
COA 取扱説明書

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

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Mizacorat 構造式

Mizacorat 構造式

CAS 番号 : 1893415-00-3

容量 価格(税別) 在庫状況
5 mg USD 650 見積もりとリードタイムを求めるのご確認
10 mg USD 950 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

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製品説明

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].

IC50 & Target

IC50: 3.8 nM (Glucocorticoid receptor)[1].

体内実験

Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW[1].
Dosage: 15 mg/kg/day.
Administration: Oral gavage daily for 8 days.
Result: Inhibited ankle swelling in the rat SCW model.
臨床実験
分子量

494.53

分子式

C27H28F2N4O3

CAS 番号
SMILES

CC(F)(F)C(N[[email protected]]([[email protected]](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)C(C)C)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (202.21 mM; Need ultrasonic)

H2O : 0.67 mg/mL (1.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0221 mL 10.1106 mL 20.2212 mL
5 mM 0.4044 mL 2.0221 mL 4.0442 mL
10 mM 0.2022 mL 1.0111 mL 2.0221 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

*All of the co-solvents are available by MCE.
純度とドキュメンテーション
参考文献
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製品名:
Mizacorat
製品番号:
HY-120012
数量:
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