1. GPCR/G Protein
  2. Adrenergic Receptor

Amezinium methylsulfate (Synonyms: Amezinium metilsulfate; Lu-1631)

Cat. No.: HY-A0275
Handling Instructions

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.

For research use only. We do not sell to patients.
Amezinium methylsulfate Chemical Structure

Amezinium methylsulfate Chemical Structure

CAS No. : 30578-37-1

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10 mM * 1 mL in DMSO $55 In-stock
100 mg $50 In-stock
500 mg $70 In-stock
1 g $95 In-stock
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Description

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptors Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia.

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.1915 mL 15.9576 mL 31.9152 mL
5 mM 0.6383 mL 3.1915 mL 6.3830 mL
10 mM 0.3192 mL 1.5958 mL 3.1915 mL
References
M.Wt

313.33

Formula

C₁₂H₁₅N₃O₅S

CAS No.

30578-37-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Amezinium methylsulfate
Cat. No.:
HY-A0275
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