1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Fenmetozole Tosylate

Fenmetozole Tosylate 

Cat. No.: HY-U00402
Handling Instructions

Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant drug.

For research use only. We do not sell to patients.

Fenmetozole Tosylate Chemical Structure

Fenmetozole Tosylate Chemical Structure

CAS No. : 83474-08-2

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Description

Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant drug.

In Vitro

Fenmetozole acts as an antagonist of α2-adrenergic receptor[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice, fenmetozole antagonizes both the ethanol induced increase in locomotor activity at 2.0 g/kg and the decrease caused by 4.0 g/kg. Moreover, fenmetozole attenuates the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate content, but it significantly elevates cGMP levels in this tissue. Fenmetozole does not change ethanol induced increases in punished drinking in a conflict test, but when given at a high dose, fenmetozole decreases both punished and unpunished responding. Fenmetozole fails to precipitate ethanol withdrawal-like reactions when it is given to physically-dependent, intoxicated rats. Fenmetozole (15-30 g/kg) reduces ethanol-induced impairment of the aerial righting reflex without altering blood or brain ethanol content[1]. Fenmetozole alone has no ffect on punished drinking and does not alter ethanol action in the paradigm except at the highest dose tested (30 mg/kg) in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

417.31

Formula

C₁₇H₁₈Cl₂N₂O₄S

CAS No.

83474-08-2

SMILES

ClC1=CC=C(OCC2=NCCN2)C=C1Cl.O=S(C3=CC=C(C)C=C3)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FenmetozoleAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Fenmetozole Tosylate
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