Fosaprepitant dimeglumine
Based on 4 publication(s) in Google Scholar
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.42%
- CAS No.: 265121-04-8
- Formule: C37H56F7N6O16P
- Masse moléculaire:1004.83
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Stockage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-10052
AprepitantNeurokinin 1 Receptor Antagonist -
HY-16346
NetupitantNK1 Receptor Inhibitor -
HY-14751
RolapitantNK1 Receptor Antagonist -
HY-10999
TrametinibMEK Inhibitor -
HY-15531
VenetoclaxBCL-2 Inhibitor -
HY-N0178
DiosminAryl Hydrocarbon Receptor Agonist -
HY-12143
Vofopitant dihydrochlorideNK1 Receptor Inhibitor -
HY-B0069
FludarabineDNA Synthesis Inhibitor -
HY-13259
MG-132Proteasome Inhibitor -
HY-10162
OlaparibPARP Inhibitor -
HY-17359
DeferasiroxIron Chelator -
HY-13805
PP2Src Inhibitor
Publications Citing Use of MedChemExpress (MCE) Fosaprepitant dimeglumine
More
Activité biologique
Description
IC50 & Target
Neurokinin-1 receptor[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection, daily, for 7 days
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Result:Increased the antinociceptive effect of morphine compared to control group.
Chemical Information
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CAS No. 265121-04-8
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Appearance Solid
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Masse moléculaire 1004.83
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Formule C37H56F7N6O16P
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Color White to off-white
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SMILES
O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC
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Synonyms
MK-0517; L785298
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (4)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Antiemetic drug fosaprepitant exerts anti-tumor effects against NSCLC by targeting FAK to inhibit AKT and JNK/c-Jun pathways. [Abstract]2025 Sep 10. PMID: 40931041 -
Int J Biol Macromol
Inhibition of the oncogenic GTPase dynamin-related protein 1 (DRP1) by the FDA-approved drug fosaprepitant: In silico, biophysical, and in vitro characterization of its anti-myeloma activity. [Abstract]2026 Jun:369:152633. PMID: 42167430 -
Cancer Biol Ther
LncRNA RMRP silence curbs neonatal neuroblastoma progression by regulating microRNA-206/tachykinin-1 receptor axis via inactivating extracellular signal-regulated kinases. [Abstract]2019;20(5):653-665. PMID: 30582709 -
Solvant et solubilité
In Vitro:
H2O : 50 mg/mL (49.76 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (99.52 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 0.9952 mL | 4.9760 mL | 9.9519 mL | 24.8798 mL |
| 5 mM | 0.1990 mL | 0.9952 mL | 1.9904 mL | 4.9760 mL | |
| 10 mM | 0.0995 mL | 0.4976 mL | 0.9952 mL | 2.4880 mL | |
| 15 mM | 0.0663 mL | 0.3317 mL | 0.6635 mL | 1.6587 mL | |
| 20 mM | 0.0498 mL | 0.2488 mL | 0.4976 mL | 1.2440 mL | |
| 25 mM | 0.0398 mL | 0.1990 mL | 0.3981 mL | 0.9952 mL | |
| 30 mM | 0.0332 mL | 0.1659 mL | 0.3317 mL | 0.8293 mL | |
| 40 mM | 0.0249 mL | 0.1244 mL | 0.2488 mL | 0.6220 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fosaprepitant dimeglumine Related Classifications
HY-14407A Related Classifications
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