GB1107

Name: GB1107
Brand: MedChemExpress
SKU: HY-114409
Rating: 5.0 (19 reviews)

Cat. No.: HY-114409 Purity: 99.92%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a K_d of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.

For research use only. We do not sell to patients.

CAS No. : 1978336-61-6

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 19 publication(s) in Google Scholar

19 Publications Citing Use of MCE GB1107

Histological Imaging/Staining

In Vivo Efficacy Study

Cell Migration/Invasion Assay

: GB1107 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 7;16(1):7287. [Abstract]; Eight-week-old female C57BL/6 J mice were fed with a chow diet. Full-thickness skin wounds were created and i.c. injected with Gal-3 inhibitor (GB1107, 133 μM, 100 µL/mouse) or solvent control (Veh). Picrosirius red staining in healed wound.

: GB1107 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 7;16(1):7287. [Abstract]; Eight-week-old female C57BL/6 J mice were fed with a chow diet. Full-thickness skin wounds were created and i.c. injected with Gal-3 inhibitor (GB1107, 133 μM, 100 µL/mouse) or solvent control (Veh). CD31 staining in healed wound.

: GB1107 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 21;5(5):101505. [Abstract]; mIF imaging depicting the MCTC structure and distribution of CD8⁺ T cells (left), along with statistical analysis of the MCTC count (right), in C57 mice with subcutaneously implanted Hepa1-6^NC and Hepa1-6^M2Bphi tumors both with and without GB1107 (10 mg/kg, p.o.) treatment.

: GB1107 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 21;5(5):101505. [Abstract]; Overview of the tumor mass (left) and tumor growth curves (right) in the subcutaneously implanted tumors of the above groups. GB1107 (10 mg/kg, p.o.) reduced tumor burden and metastasis.

: GB1107 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 21;5(5):101505. [Abstract]; Supplemented with 1 μM GB1107, a migration assay was performed to quantify the number of macrophages that migrated when cocultured with tumor cells treated as described above at 24 h.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Galectin-3

In Vitro

Treatment with GB1107 (0-1 μM) increases tumor M1 macrophage polarization and CD8+ T cell infiltration in LLC cells by flow cytometric analysis. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GB1107 (10 mg/kg, p.o., once daily from day 18-30 post implantation) treatment results in significantly reduced tumor growth and final tumor weights^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 nude female mice received 3x10⁶ human lung adenocarcinoma cells (A549)^[1].
Dosage:	10 mg/kg
Administration:	Oral once daily from day 18-30 post implantation.
Result:	Resulted in significantly reduced tumor growth and final tumor weights.

Molecular Weight

522.32

Formula

C₂₀H₁₆Cl₂F₃N₃O₄S

CAS No.

1978336-61-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@H]3SC4=CC=C(Cl)C(Cl)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (95.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9145 mL	9.5727 mL	19.1453 mL
5 mM	0.3829 mL	1.9145 mL	3.8291 mL
10 mM	0.1915 mL	0.9573 mL	1.9145 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 4

Add each solvent one by one: 5% DMSO 40% PEG300 5% Tween-80 50% Saline
Solubility: 2.5 mg/mL (4.79 mM); Suspended solution; Need ultrasonic
Protocol 5

Add each solvent one by one: 5% DMSO 95% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (258 KB) HNMR (263 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Vuong L, et al. An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. Cancer Res. 2019 Jan 23. pii: canres.2244.2018. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9145 mL	9.5727 mL	19.1454 mL	47.8634 mL
	5 mM	0.3829 mL	1.9145 mL	3.8291 mL	9.5727 mL
	10 mM	0.1915 mL	0.9573 mL	1.9145 mL	4.7863 mL
	15 mM	0.1276 mL	0.6382 mL	1.2764 mL	3.1909 mL
	20 mM	0.0957 mL	0.4786 mL	0.9573 mL	2.3932 mL
	25 mM	0.0766 mL	0.3829 mL	0.7658 mL	1.9145 mL
	30 mM	0.0638 mL	0.3191 mL	0.6382 mL	1.5954 mL
	40 mM	0.0479 mL	0.2393 mL	0.4786 mL	1.1966 mL
	50 mM	0.0383 mL	0.1915 mL	0.3829 mL	0.9573 mL
	60 mM	0.0319 mL	0.1595 mL	0.3191 mL	0.7977 mL
	80 mM	0.0239 mL	0.1197 mL	0.2393 mL	0.5983 mL

GB1107 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GB11071978336-61-6GB 1107GB-1107GalectinInhibitorinhibitorinhibit

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GB1107

Customer Review

GB1107 Related Antibodies

19 Publications Citing Use of MCE GB1107

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Galectin Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

GB1107 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

GB1107 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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