IFN alpha-IFNAR-IN-1 hydrochloride

Name: IFN alpha-IFNAR-IN-1 hydrochloride
Brand: MedChemExpress
SKU: HY-12836A
Rating: 5.0 (25 reviews)

製品番号: HY-12836A 純度: 99.76%: Data Sheet SDS COA 取扱説明書
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IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC₅₀=2-8 μM).

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CAS 番号 : 2070014-98-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 130	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 130	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$119	在庫あり	Estimated Time of Arrival: December 31
10 mg	$158	在庫あり	Estimated Time of Arrival: December 31
25 mg	$280	在庫あり	Estimated Time of Arrival: December 31
50 mg	$422	在庫あり	Estimated Time of Arrival: December 31
100 mg	$739	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 25 publication(s) in Google Scholar

Other Forms of IFN alpha-IFNAR-IN-1 hydrochloride:

IFN alpha-IFNAR-IN-1 在庫あり

顧客検証

: IFN alpha-IFNAR-IN-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Jul 14;6:29665. [Abstract]; PAMs are first pretreated with IFN-alpha-IFNAR-IN-1 or mock pretreated with medium containing DMSO for 2 h. The cells are then infected with the HP-PRRSV virus at an MOI of 5 or mock-infected with DMEM for 12 h and 16 h, respectively. The cell lysates are collected and analyzed by western blot. The fold change of SAMHD1 protein is expressed as densitometric units of the band normalized to the β-actin level relative to the uninfected control. The error bar represents standard deviation from three

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製品説明

体外実験

IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) hydrochloride specifically inhibits MVA-induced IFN-a responses by BMpDCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.86

分子式

C₁₈H₁₈ClNS

CAS 番号

2070014-98-9

Appearance

Solid

Color

White to off-white

SMILES

CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (316.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 16.67 mg/mL (52.78 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1660 mL	15.8298 mL	31.6596 mL
5 mM	0.6332 mL	3.1660 mL	6.3319 mL
10 mM	0.3166 mL	1.5830 mL	3.1660 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.76%

Select Batch:

データシート (276 KB) SDS (252 KB)

COA (253 KB) HNMR (189 KB) LCMS (340 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.1660 mL	15.8298 mL	31.6596 mL	79.1490 mL
	5 mM	0.6332 mL	3.1660 mL	6.3319 mL	15.8298 mL
	10 mM	0.3166 mL	1.5830 mL	3.1660 mL	7.9149 mL
	15 mM	0.2111 mL	1.0553 mL	2.1106 mL	5.2766 mL
	20 mM	0.1583 mL	0.7915 mL	1.5830 mL	3.9574 mL
	25 mM	0.1266 mL	0.6332 mL	1.2664 mL	3.1660 mL
	30 mM	0.1055 mL	0.5277 mL	1.0553 mL	2.6383 mL
	40 mM	0.0791 mL	0.3957 mL	0.7915 mL	1.9787 mL
	50 mM	0.0633 mL	0.3166 mL	0.6332 mL	1.5830 mL
DMSO	60 mM	0.0528 mL	0.2638 mL	0.5277 mL	1.3191 mL
	80 mM	0.0396 mL	0.1979 mL	0.3957 mL	0.9894 mL
	100 mM	0.0317 mL	0.1583 mL	0.3166 mL	0.7915 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.