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KZR-504 

Cat. No.: HY-101786
Handling Instructions

KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively.

For research use only. We do not sell to patients.

KZR-504 Chemical Structure

KZR-504 Chemical Structure

CAS No. : 1629052-78-3

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively.

IC50 & Target

IC50: 51 nM (LMP2), 4.274 μM (LMP7)[1].

In Vivo

Evaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 (compound 12) is both selective and potent in vivo with >50% target inhibition achieved at >1 mg/kg in all tissues tested except brain[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4188 mL 12.0942 mL 24.1885 mL
5 mM 0.4838 mL 2.4188 mL 4.8377 mL
10 mM 0.2419 mL 1.2094 mL 2.4188 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

413.42

Formula

C₂₁H₂₃N₃O₆

CAS No.

1629052-78-3

SMILES

O=C(N[[email protected]@H](CO)C(N[[email protected]@H](CC1=CC=CC=C1)C([[email protected]]2(CO2)C)=O)=O)C(N3)=CC=CC3=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
KZR-504
Cat. No.:
HY-101786
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KZR-504

Cat. No.: HY-101786