Lesinurad sodium
Based on 5 publication(s) in Google Scholar
Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
For research use only. We do not sell to patients.
- Purity : 99.79%
- CAS No.: 1151516-14-1
- Formula: C17H13BrN3NaO2S
- Molecular Weight:426.26
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-15258
LesinuradURAT1 Inhibitor -
HY-16733
VerinuradURAT1 Inhibitor -
HY-16733R
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HY-111345
EpaminuradURAT1 Inhibitor -
HY-N3513
MulberrinOATP2B1 Inhibitor -
HY-153971
URAT1 inhibitor 8URAT1 Inhibitor -
HY-144305
KPH2fURAT1/GLUT9 Inhibitor -
HY-147422
XininuradURAT1 Inhibitor -
HY-W052011
RuzinuradURAT1 Inhibitor -
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HY-147300
PuliginuradURAT Inhibitor -
HY-153969
URAT1 inhibitor 6URAT1 Inhibitor
Publications Citing Use of MedChemExpress (MCE) Lesinurad sodium
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Biological Activity
Description
IC50 & Target
Km: 0.85 µM (OAT1), 2 µM (OAT3)[1]
In Vitro
Lesinurad is a novel selective uric acid reabsorption inhibitor (SURI). Lesinurad is determined to be a substrate for the kidney transporters organic anion transporter (OAT1) and OAT3 with Km values of 0.85 and 2 μM, respectively[1]. Lesinurad (RDEA594) is a URAT1 and OAT inhibitor, which increases proximal renal tubule urate excretion[2]. Lesinurad (RDEA594) is a potential uric acid lowering agent througn inhibition of uric acid reuptake, and exhibits favorable p450 profiles, inhibits CYP2C9 and CYP2C8 with IC50 of 14.4 μM and 16.2 μM, respectively. IC50s of Lesinurad are all above 100 μM for CYP1A2, CYP2C19,and CYP2D6[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1151516-14-1
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Appearance Solid
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Molecular Weight 426.26
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Formula C17H13BrN3NaO2S
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Color White to off-white
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SMILES
O=C(O[Na])CSC1=NN=C(Br)N1C2=C3C=CC=CC3=C(C4CC4)C=C2
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Synonyms
RDEA-594 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Jul 16;16(1):6551. PMID: 40670375 -
Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
Food Funct
Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells. [Abstract]2019 Aug 1;10(8):5215-5227. PMID: 31384856 -
Bioorg Chem
Discovery of digallic acid as XOD/URAT1 dual target inhibitor for the treatment of hyperuricemia. [Abstract]2024 Jun:147:107381. PMID: 38669781 -
Toxicol Appl Pharmacol
2025 May 4:500:117371. PMID: 40328338
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (234.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.86 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.86 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52 [Content Brief]
[2]. Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8(4):145-59. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3460 mL | 11.7299 mL | 23.4599 mL | 58.6496 mL |
| 5 mM | 0.4692 mL | 2.3460 mL | 4.6920 mL | 11.7299 mL | |
| 10 mM | 0.2346 mL | 1.1730 mL | 2.3460 mL | 5.8650 mL | |
| 15 mM | 0.1564 mL | 0.7820 mL | 1.5640 mL | 3.9100 mL | |
| 20 mM | 0.1173 mL | 0.5865 mL | 1.1730 mL | 2.9325 mL | |
| 25 mM | 0.0938 mL | 0.4692 mL | 0.9384 mL | 2.3460 mL | |
| 30 mM | 0.0782 mL | 0.3910 mL | 0.7820 mL | 1.9550 mL | |
| 40 mM | 0.0586 mL | 0.2932 mL | 0.5865 mL | 1.4662 mL | |
| 50 mM | 0.0469 mL | 0.2346 mL | 0.4692 mL | 1.1730 mL | |
| 60 mM | 0.0391 mL | 0.1955 mL | 0.3910 mL | 0.9775 mL | |
| 80 mM | 0.0293 mL | 0.1466 mL | 0.2932 mL | 0.7331 mL | |
| 100 mM | 0.0235 mL | 0.1173 mL | 0.2346 mL | 0.5865 mL |
Lesinurad sodium Related Classifications
HY-15258A Related Classifications
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