2. Signaling Pathways
  3. GPCR/G Protein
  4. Class C GPCR

Class C GPCR

Synonyms: Glutamate Family

Class C (glutamate) GPCRs are defined by two unique structural features: first, they possess a large extracellular domain (ECD) that is distal to the 7TM and contains the orthosteric sites; second, they form constitutive dimers with unique activation modes compared with other classes of GPCRs. Class C GPCRs are further divided into 5 subfamilies including 1 calcium-sensing receptor (CaSR), 2 γ-aminobutyric acid (GABA) type B receptors (GABAB1 and GABAB2), 3 taste 1 receptors (TS1R1–3), 8 metabotropic glutamate receptors (mGluR1–8), and 8 orphan GPCRs.