Infection

Phenelfamycins F is an antibiotic with anti-eutrophic bacterial activity.

YZK-C22, containing a 1,2,3-thiadiazol-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole skeleton, is a fungicide lead compound with broad-spectrum fungicidal activity.

Cytochalasin D (Standard) is the analytical standard of Cytochalasin D (HY-N6682). This product is intended for research and analytical applications. Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap.

MCPA-isooctyl is a selective conductive phenoxycarboxylate herbicide and an alternative to 2,4-D Butyl ester (HY-B0867). MCPA-isooctyl effectively controls broadleaf weeds in various crop fields via post-emergence foliar or soil treatment. MCPA-isooctyl is absorbed by the roots, stems and leaves of plants; it is easily metabolized and detoxified in gramineous crops, but difficult to metabolize in dicotyledonous weeds, causing stem and leaf distortion, root deformation, and eventually weed death. When formulated into chitosan nanoparticles, MCPA-isooctyl still significantly inhibits the growth of weeds in wheat fields, and reduces their chlorophyll content and biomass at low doses.

Eltrombopag (Olamine) (Standard) is the analytical standard of Eltrombopag (Olamine). This product is intended for research and analytical applications. Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag Olamine can be used for the research of cardiovascular. Eltrombopag Olamine also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well.

Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and a glutathione S-transferase pi 1 (GSTP1) inhibitor (IC₅₀=40 μg/mL for human GSTP1).

Dirithromycin (Standard) is the analytical standard of Dirithromycin. This product is intended for research and analytical applications. Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis.

SARS-CoV-2 nsp14-IN-6 (Compound 35) is a SARS-CoV-2 Nsp14 MTase inhibitor with an IC₅₀ of 0.24  μM. SARS-CoV-2 nsp14-IN-6 has potent antiviral activity against SARS-CoV-2 replication. SARS-CoV-2 nsp14-IN-6 increases lipophilicity, further improving cell permeability. SARS-CoV-2 nsp14-IN-6 can be used for human coronaviruses research.

Antifungal agent 159 is an antifungal agent with broad-spectrum activity against phytopathogenic fungi. Antifungal agent 159 binds tightly to the active sites of exo-β-(1,3)-glucanase, topoisomerase II-DNA-nucleotide, dihydrofolate reductase, sterol 14-α demethylase and chitin synthase. Antifungal agent 159 can be used in studies related to phytopathogenic fungal infections.

SARS-CoV-2 Mpro-IN-13 (compound 20j) is a covalent SARS-CoV-2 Protease Mpro inhibitor with an IC₅₀ value of 19.0 nM. SARS-CoV-2 Mpro-IN-13 processes antiviral activity with an EC₅₀ value of 138.1 nM.

Pyrrolosporin A is an antibiotic. Pyrrolosporin A has weak anti-Gram-negative bacteria activity.

Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer.

Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

AzddMeC (Standard) is the analytical standard of AzddMeC (HY-105268). This product is intended for research and analytical applications. AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1-infected human PBM cells and HIV-1-infected human macrophages, the EC₅₀ values of AzddMeC are 9 nM and 6 nM, respectively. AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Helvecardin B is a glycopeptidtic antibiotic. Helvecardin B has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus.

3-Cyanochromone (Compound fragment 1) is a dual NDM-1 and VIM-2 inhibitor with K_D values of 181 μM and 999 μM, respectively. 3-Cyanochromone is promising for research of antibiotics.