1. Anti-infection
    Cell Cycle/DNA Damage
  2. HIV
    Reverse Transcriptase
    Nucleoside Antimetabolite/Analog
  3. AzddMeC

AzddMeC (Synonyms: CS-92)

Cat. No.: HY-105268
Handling Instructions

AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1-infected human PBM cells and HIV-1-infected human macrophages, the EC50 values of AzddMeC are 9 nM and 6 nM, respectively.

For research use only. We do not sell to patients.

AzddMeC Chemical Structure

AzddMeC Chemical Structure

CAS No. : 87190-79-2

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Description

AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1-infected human PBM cells and HIV-1-infected human macrophages, the EC50 values of AzddMeC are 9 nM and 6 nM, respectively[1][2].

IC50 & Target[1]

HIV-1

9 nM (EC50, Human PBM cells)

HIV-1

6 nM (EC50, Human macrophages)

In Vitro

AzddMeC (CS-92) is also effective against HIV-2 in lymphocytes. The replication of Friend murine virus is only weakly inhibited, and no effect is observed against HSV type 1 and type 2 and coxsackievirus B4. The interaction of the 5'-triphosphate of AzddMeC with HIV-1 reverse transcriptase indicated competitive inhibition (the inhibition constant, Kis, is 9.3 nM)[1].

In Vivo

The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%[2].

Molecular Weight

266.26

Formula

C₁₀H₁₄N₆O₃

CAS No.

87190-79-2

SMILES

O=C1N([[email protected]]2C[[email protected]](N=[N+]=[N-])[[email protected]@H](CO)O2)C=C(C)C(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AzddMeCCS-92CS92CS 92HIVReverse TranscriptaseNucleoside Antimetabolite/AnalogHuman immunodeficiency virusHIV-1nucleosideanalogAZTantiviralreversetranscriptasereplicationHIV-2Inhibitorinhibitorinhibit

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AzddMeC
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HY-105268
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