SLV-2436
Based on 1 Customer Validation
SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.
For research use only. We do not sell to patients.
- Purity : 98.03%
- CAS No.: 2095704-43-9
- Formula: C19H15ClN4O
- Molecular Weight:350.80
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
MNK2 5.4 nM (IC50) |
MNK1 10.8 nM (IC50) |
In Vitro
To confirm the kinome selectivity of SLV-2436 (SEL201), the broad KINOMEscan competitive binding assay is performed at 1 μM, which includes 450 distinct kinases. The observed binding profile for SLV-2436 is significantly concentrated in the CAMK family of kinases that comprises MNK1 and MNK2. SLV-2436-treated KIT-mutant melanoma cells have lower oncogenicity and reduced metastatic ability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2095704-43-9
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Appearance Solid
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Molecular Weight 350.80
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Formula C19H15ClN4O
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Color Light brown to brown
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SMILES
O=C1C=CC(C2=CC3=C(C=C2)C(N)=NN3)=CN1CC4=CC=CC(Cl)=C4
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Synonyms
SEL201-88; SEL-201
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (285.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8506 mL | 14.2531 mL | 28.5063 mL | 71.2657 mL |
| 5 mM | 0.5701 mL | 2.8506 mL | 5.7013 mL | 14.2531 mL | |
| 10 mM | 0.2851 mL | 1.4253 mL | 2.8506 mL | 7.1266 mL | |
| 15 mM | 0.1900 mL | 0.9502 mL | 1.9004 mL | 4.7510 mL | |
| 20 mM | 0.1425 mL | 0.7127 mL | 1.4253 mL | 3.5633 mL | |
| 25 mM | 0.1140 mL | 0.5701 mL | 1.1403 mL | 2.8506 mL | |
| 30 mM | 0.0950 mL | 0.4751 mL | 0.9502 mL | 2.3755 mL | |
| 40 mM | 0.0713 mL | 0.3563 mL | 0.7127 mL | 1.7816 mL | |
| 50 mM | 0.0570 mL | 0.2851 mL | 0.5701 mL | 1.4253 mL | |
| 60 mM | 0.0475 mL | 0.2376 mL | 0.4751 mL | 1.1878 mL | |
| 80 mM | 0.0356 mL | 0.1782 mL | 0.3563 mL | 0.8908 mL | |
| 100 mM | 0.0285 mL | 0.1425 mL | 0.2851 mL | 0.7127 mL |
SLV-2436 Related Classifications
HY-112113 Related Classifications
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