Arginase Inhibitor

2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM.

Numidargistat (Standard) is the analytical standard of Numidargistat (HY-101979). This product is intended for research and analytical applications. Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent.

ABH is an orally active arginase inhibitor (K_i = 8.5 nM). ABH promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1). ABH improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis.

Piceatannol 3'-O-glucoside (Standard) is the analytical standard of Piceatannol 3'-O-glucoside. This product is intended for research and analytical applications. Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC₅₀s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.

DL-Norvaline (Standard) is the analytical standard of DL-Norvaline. This product is intended for research and analytical applications. DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

L-Valine-1-¹³C,¹⁵N ((S)-Valine-1-¹³C,¹⁵N) is the ¹³C- and ¹⁵N-labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism.

NG-Hydroxy-L-arginine acetate (NOHA acetate) serves as a physiological inhibitor of arginase, playing a crucial role in the conversion of arginine to nitric oxide and citrulline by nitric oxide synthase.