Arginase Inhibitor

ARG1-IN-1 (Compound 3) hydrochloride is an orally active arginase inhibitor with an IC₅₀ value of 29 nM. ARG1-IN-1 hydrochloride can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 hydrochloride is applicable for tumor research.

L-Norvaline-d₅ is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.

Aureusidin is a flavonoid compound that is isolated and extracted from Antirrhinum majus and exhibits oral activity. Aureusidin possesses antioxidant, neuroprotective, and anti-inflammatory properties. Aureusidin directly targets and binds MD2 and Caspase-3 with high affinity, synergistically inhibits the TLR4/NF-κB inflammatory pathway and GSDME-mediated pyroptosis, and activates the Nrf2/HO-1 antioxidant axis via the ROS/MAPKs pathway. Aureusidin is a bovine liver arginase inhibitor with an IC₅₀ of 57.1 µM. Aureusidin is used for research on inflammation-related diseases (osteoarthritis), acute liver injury, and endothelial dysfunction.

OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC₅₀s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study.

ARG1-IN-1 (Compound 3) is an orally active arginase inhibitor with an IC₅₀ value of 29 nM. ARG1-IN-1 can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 is applicable for tumor research.

NED-3238 is a highly potent arginase I and II inhibitor with IC₅₀ values of 1.3 nM and 8.1 nM, respectively.

Arginase inhibitor 2 hydrochloride is an Arginase inhibitor. Arginase inhibitor 2 hydrochloride synergizes with adoptively transferred antigen- specific T cells to inhibit tumor growth.

L-Valine-¹⁵N,d₈ ((S)-Valine-¹⁵N,d₈) is the deuterium and ¹⁵N labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

L-Valine-¹³C₅,¹⁵N,d₈ ((S)-Valine-¹³C₅,¹⁵N,d₈) is the deuterium, ¹³C-, and ¹⁵N-labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

(-)-3-O-Acetylcatechin is a Leishmania amazonensis arginase inhibitor with an IC₅₀ of 3.7 μM. (-)-3-O-Acetylcatechin can be used for the research of leishmaniasis.

L-Valine-2-¹³C ((S)-Valine-2-¹³C) is the ¹³C-labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

Arginase inhibitor 7 (compound A17) is an arginase (ARG1) inhibitor, with an IC₅₀ of 0.16 μM. Arginase inhibitor 7 has high oral bioavailability.

L-Valine-d₁ ((S)-Valine-d₁) is the deuterium labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

AZD0011-PL is a human arginase 1/ 2 inhibitor with IC₅₀ values of 0.01 μM and 0.02 μM. AZD0011-PL can be used for the researches of cancer, respiratory inflammatory disease.

BEC, an arginine analogue, is a slow-binding competitive inhibitor of the binuclear manganese metalloenzyme arginase. BEC enhances substrate flux to NO synthase, thereby enhancing NO-dependent smooth muscle relaxation in the corpus cavernosum, and enhances penile erection.

L-Norvaline (Standard) is the analytical standard of L-Norvaline (HY-Y0399). This product is intended for research and analytical applications. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.

Arginase inhibitor 2 is an Arginase inhibitor. Arginase inhibitor 2 synergizes with adoptively transferred antigen- specific T cells to inhibit tumor growth.

L-Valine-¹³C₅,¹⁵N,d₂ ((S)-Valine-¹³C₅,¹⁵N,d₂) is the deuterium, ¹³C-, and ¹⁵N-labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

Arginase inhibitor 9 (Compound 12a) is an arginase inhibitor with IC₅₀ values of 9 μM and 55 μM for bovine and human arginase I, respectively. Arginase inhibitor 9 exhibits antioxidant activity and can scavenge free radicals. Additionally, Arginase inhibitor 9 can effectively regulate the levels of collagen and procollagen, exerting an anti-fibrotic effect.

AZD0011, a prodrug of AZD0011-PL (HY-182718), is an orally active arginase 1 inhibitor with an IC₅₀ of 328 nM. AZD0011 undergoes in vivo hydrolysis to release an arginase inhibitor payload, inhibiting arginine hydrolysis, increases arginine levels in plasma and the tumor microenvironment. AZD0011 restores innate immune function and inhibits tumor growth. AZD0011 can be used for the research of cancer, such as fibrosarcoma.