38216-54-5
Chemical Structure
Aureusidin
- CAS No.: 38216-54-5
- Formula:C15H10O6
- Molecular Weight:286.24
IUPAC Name: (Z)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxybenzofuran-3(2H)-one
InChIKey: WBEFUVAYFSOUEA-PQMHYQBVSA-N
SMILES: O=C1C2=C(O)C=C(O)C=C2O/C1=C\C3=CC(O)=C(C=C3)O
Biological Activity: Aureusidin is a flavonoid compound that is isolated and extracted from Antirrhinum majus and exhibits oral activity. Aureusidin possesses antioxidant, neuroprotective, and anti-inflammatory properties. Aureusidin directly targets and binds MD2 and Caspase-3 with high affinity, synergistically inhibits the TLR4/NF-κB inflammatory pathway and GSDME-mediated pyroptosis, and activates the Nrf2/HO-1 antioxidant axis via the ROS/MAPKs pathway. Aureusidin is a bovine liver arginase inhibitor with an IC50 of 57.1 µM. Aureusidin is used for research on inflammation-related diseases (osteoarthritis), acute liver injury, and endothelial dysfunction[1][2][3][4].
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Aureusidin | 97.01% | Aureusidin is a flavonoid compound that is isolated and extracted from Antirrhinum majus and exhibits oral activity. Aureusidin possesses antioxidant, neuroprotective, and anti-inflammatory properties. Aureusidin directly targets and binds MD2 and Caspase-3 with high affinity, synergistically inhibits the TLR4/NF-κB inflammatory pathway and GSDME-mediated pyroptosis, and activates the Nrf2/HO-1 antioxidant axis via the ROS/MAPKs pathway. Aureusidin is a bovine liver arginase inhibitor with an IC50 of 57.1 µM. Aureusidin is used for research on inflammation-related diseases (osteoarthritis), acute liver injury, and endothelial dysfunction. | ||||||||||||||||||||
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References
- [1]. Arraki K, et al. Mammalian Arginase Inhibitory Activity of Methanolic Extracts and Isolated Compounds from Species. Molecules (Basel, Switzerland). 2021 Mar 18;26(6):1694. [Content Brief]
- [2]. Feng S, et al. Aureusidin protects against osteoarthritis via Caspase-3/gasdermin E-mediated pyroptosis. Toxicology and applied pharmacology. 2026 Sep;514:117911. [Content Brief]
- [3]. Ren J, et al. Anti-inflammatory effects of Aureusidin in LPS-stimulated RAW264.7 macrophages via suppressing NF-κB and activating ROS- and MAPKs-dependent Nrf2/HO-1 signaling pathways. Toxicology and applied pharmacology. 2020 Jan 15;387:114846.
- [4]. Yang Y, et al. The Mechanism of Aureusidin in Suppressing Inflammatory Response in Acute Liver Injury by Regulating MD2. Frontiers in pharmacology. 2020;11:570776.
