CCR Inhibitor
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PNU-177864
0 ImagesCat. No.: HY-103406CAS No.: 250266-51-4PNU-177864 is a potent, selective, orally active dopamine D3 receptor antagonist. PNU-177864 induces phospholipid metabolism in vivo and has anti-schizophrenia activity.
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CM369
0 ImagesCat. No.: HY-P992334
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TC6-D3
0 ImagesCat. No.: HY-P11928CAS No.: 3121532-43-9TC6-D3 is a proteolysis-resistant peptide and also a CC chemokine receptor 7 (CCR7) inhibitor, with a Kd value of 403 nM against mouse targets. TC6-D3 blocks the interaction between CCR7 and its ligands CCL19 and CCL21, and inhibits the activation of the ERK1/2 pathway. TC6-D3 reduces the migratory capacity of tumor cells in vitro. TC6-D3 inhibits tumor growth and lymph node metastasis in vivo. TC6-D3 restores T cell cytotoxicity, promotes CD8+ T cell infiltration, and enhances anti-tumor immune responses. TC6-D3 can be used in studies related to lymph node metastasis.
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PLS-123
0 ImagesCat. No.: HY-120406CAS No.: 1431727-04-6LPS-123 is a covalently irreversible BTK inhibitor with an IC50 of < 5 nM. LPS-123 simultaneously inhibits the catalytic activity of BTK at Tyr551 and its self-activation at Tyr223. LPS-123 inhibits phosphorylation of the AKT/mTOR and MAPK signaling pathways, activation of PLCγ2, ERK1/2, p38, AKT, and mTOR, and blocks the production of CCL3 and CCL4 chemokines. LPS-123 exhibits significant anti-proliferative activity against various B-cell lymphoma cell lines and effectively induces apoptosis via a caspase-dependent pathway. LPS-123 also demonstrates significant antitumor activity in the OCI-Ly7 xenograft model. LPS-123 can be used for lymphoma research.
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TAK-661
0 ImagesCat. No.: HY-159927CAS No.: 175215-34-6TAK-661 is a inhibitor of eosinophil chemotaxis. TAK-661 significantly reduces the bronchoconstriction during the late phase, along with the inhibition of eosinophilia in bronchoalveolar lavage (BAL) and the eosinophil infiltration into the airway wall.
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VCH-286
0 ImagesCat. No.: HY-15571ACAS No.: 891824-47-8VCH-286 is a CCR5 inhibitor that exhibits potent in vitro anti-HIV-1 activity when used alone.
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CMPD167
0 ImagesCat. No.: HY-124848CAS No.: 313994-79-5Synonyms: MRK-1
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ZL-1218 (FUT8-KO)
0 ImagesCat. No.: HY-P991944AZL-1218 (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody. ZL-1218 (FUT8-KO) can be used for the research of solid tumour.
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Anti-CCR5 Antibody (HEK/1/85a/7a)
0 ImagesCat. No.: HY-P991843Anti-CCR5 Antibody (HEK/1/85a/7a) recognizes an epitope on human CCR5. CCR5 is a seven-transmembrane G-protein-coupled receptor (GPCR). Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
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MR2938
0 ImagesCat. No.: HY-149087CAS No.: 1044870-65-6
