Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
All Product Categories
-
Calcium Channel Inhibitors
(593)
View all products
-
Calcium Channel Agonists
(35)
View all products
-
Calcium Channel Antagonists
(209)
View all products
-
Calcium Channel Activators
(88)
View all products
-
Calcium Channel Modulators
(45)
View all products
-
Calcium Channel Chemical
(1)
View all products
-
Calcium Channel Inducers
(12)
View all products
-
Calcium Channel Controls
(10)
View all products
-
Calcium Channel Ligands
(7)
View all products
-
Calcium Channel Related Products (1237)
Related Products (1237)
-
Antibodies (29)
-
Related Compound Screening Libraries (1)
-
Calcium Channel Isoform Comparison
-
(S)-Albuterol
0 ImagesCat. No.: HY-137311ACAS No.: 34271-50-6(S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle.
-
AJG049 free base
0 ImagesCat. No.: HY-167203CAS No.: 195991-49-2AJG049 free base is a calcium channel (Ca2+ channel) antagonist. AJG049 free base regulates vascular relaxation, reduces cardiac load, and improves cardiac perfusion by binding to the binding site of L-type calcium channels, specifically Diltiazem (HY-B0632). AJG049 free base can be used in cardiovascular disease research.
-
MRS 1523 (Standard)
0 ImagesCat. No.: HY-121119RCAS No.: 212329-37-8MRS 1523 (Standard) is the analytical standard of MRS 1523. This product is intended for research and analytical applications. MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons.
-
Barnidipine hydrochloride (Standard)
0 ImagesCat. No.: HY-107322RCAS No.: 104757-53-1Synonyms: Mepirodipine hydrochloride (Standard); YM-09730-5 (Standard)Barnidipine hydrochloride (Standard) (Mepirodipine hydrochloride (Standard)) is the analytical standard of Barnidipine (hydrochloride) (HY-107322). This product is intended for research and analytical applications. Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance.
-
Bepridil-d5 hydrochloride
0 ImagesCat. No.: HY-103315SSynonyms: CERM 1978-d5; Org 5730-d5 hydrochlorideBepridil-d5 hydrochloride (CERM 1978-d5; Org 5730-d5 hydrochloride) is the deuterated-labeled Bepridil hydrochloride (HY-103315). Bepridil hydrochloride (CERM 1978; Org 5730 hydrochloride) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoKATP/sarcKATP channels. Bepridil hydrochloride acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection.
-
D-myo-Inositol-1,2-diphosphate sodium
0 ImagesCat. No.: HY-W787880CAS No.: 208584-51-4Synonyms: Ins(1,2)P2 sodiumD-myo-Inositol-1,2-diphosphate (Ins(1,2)P2) sodium is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals.
-
Amlodipine metabolite
0 ImagesCat. No.: HY-W704938CAS No.: 113994-45-9
-
Nesapidil
0 ImagesCat. No.: HY-187768CAS No.: 90326-85-5Nesapidil is an antiarrhythmic agent and calcium channel blocker. Nesapidil slows calcium channel activity, which in turn causes slowing of atrioventricular conduction and sinus heart rate. Nesapidil alters preload, afterload, contractility, and coronary blood flow. Nesapidil can be used in research related to arrhythmia and hypertension.
-
Flunarizine (Standard)
0 ImagesFlunarizine (Standard) is the analytical standard of Flunarizine. This product is intended for research and analytical applications. Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
-
Nisoldipine-d4
0 ImagesCat. No.: HY-17402S1CAS No.: 1219795-47-7Nisoldipine-d4 (BAY-k 5552-d4) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
-
Diproteverine
0 ImagesCat. No.: HY-114638CAS No.: 69373-95-1Synonyms: BRL 40015Diproteverine (BRL 40015) is an oral activity calcium channel blocker. Diproteverine embryonic toxicity. Diproteverine also shows antianginal properties.
-
(2R/S)-6-PNG (Standard)
0 ImagesCat. No.: HY-115681RCAS No.: 68682-01-9Synonyms: 6-Prenylnaringenin (Standard); (±)-6-Prenylnaringenin (Standard)(2R/S)-6-PNG (Standard) is the analytical standard of (2R/S)-6-PNG. This product is intended for research and analytical applications. (2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca2+ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.
-
Rhodojaponin VI
0 ImagesRhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G. Don
(Ericaceae) (RM). Rhodojaponin VI binds rat N-Ethylmaleimide-sensitive fusion (NSF) with a Kd of 1.03 μM. Rhodojaponin VI blocks the MDM2-Notch1 signalling pathway by reducing MDM2 and Notch1 expression. Rhodojaponin VI indirectly reduces Cav2.2 current intensity by inhibiting NSF-mediated Cav2.2 trafficking. Rhodojaponin VI alleviates glomerulonephritis progression and podocyte injury in passive heymann nephritis rats. Rhodojaponin VI also has antinociceptive effects. Rhodojaponin VI can be used for the researches of heymann nephritis and pain.
-
TTA-Q6(isomer) (Standard)
0 ImagesCat. No.: HY-10388ARCAS No.: 910484-32-1TTA-Q6(isomer) (Standard) is the analytical standard of TTA-Q6(isomer) (HY-10388A). This product is intended for research and analytical applications. TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist.
-
Glycerophosphoinositol 4,5-diphosphate trisodium
0 ImagesCat. No.: HY-171899ASynonyms: GroPI(4,5)P2 trisodium; GPIP2 trisodiumGlycerophosphoinositol 4,5-diphosphate (GroPI(4,5)P2) trisodium is a slowly metabolized analog of InsP3. Glycerophosphoinositol 4,5-diphosphate trisodium has an EC50 of 1.228 μM for inducing calcium release, with a degradation time constant of 13 seconds. Glycerophosphoinositol 4,5-diphosphate trisodium can be used to study the effect of InsP3 degradation on calcium signal recovery.
-
PD-151307
0 ImagesCat. No.: HY-118974CAS No.: 225925-12-2PD-151307 is an N-type calcium channel antagonist with significant inhibitory effects in IMR-32 human neuroblastoma cells, exhibiting an IC50 of 0.32 µM. PD-151307 can be used in research related to cancer therapy, anticonvulsants, and neuropathic pain.
-
Gabapentin enacarbil (Standard)
0 ImagesCat. No.: HY-16216RCAS No.: 478296-72-9Synonyms: XP-13512 (Standard)Gabapentin enacarbil (Standard) is the analytical standard of Gabapentin enacarbil. This product is intended for research and analytical applications. Gabapentin enacarbil (XP-13512) is a prodrug of Gabapentin (HY-A0057) designed to be absorbed throughout the intestine by high-capacity nutrient transporters. Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin enacarbil can be used for the study of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
-
NNC 09-0026
0 ImagesCat. No.: HY-187014CAS No.: 141360-03-4NNC 09-0026 is a neuronal calcium channel inhibitor. NNC 09-0026 exhibits IC50 values of 10 μM and 13 μM against neuronal L-type voltage-gated calcium channels, and an IC50 value of 13 μM against rat neuronal N-type voltage-gated calcium channels, with higher selectivity for neuronal L-type channels over peripheral L-type channels. NNC 09-0026 inhibits voltage-dependent Ca2+ channel currents, blocks Ca2+ influx through neuronal L-type and N-type voltage-gated calcium channels, and reduces potassium-stimulated calcium uptake in rat cerebral cortex synaptosomes. NNC 09-0026 inhibits TTX-sensitive Na+ channel currents in rat cerebellar Purkinje neurons. NNC 09-0026 attenuates ischemia-induced neuronal death, infarct volume and neurological deficits in rat models of cerebral ischemia. NNC 09-0026 can be used for studies on global cerebral ischemia, focal ischemia and cerebral ischemia-related research.
-
Hypaconitine (Standard)
0 ImagesHypaconitine (Standard) is the analytical standard of Hypaconitine. This product is intended for research and analytical applications. Hypaconitine inhibits the KCNH2 current with an IC50 of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-κB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active.
-
Nilvadipine (Standard)
0 ImagesSynonyms: FK235 (Standard); FR34235 (Standard)Nilvadipine (Standard) is the analytical standard of Nilvadipine. This product is intended for research and analytical applications. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
