Casein Kinase
Casein Kinases (CKs), a group of ubiquitous Ser/Thr kinases, regulate a wide range of cellular functions in eukaryotes, including phosphorylation of proteins that are substrates for degradation via the ubiquitin-proteasome system (UPS). Two casein kinases, casein kinase-1 (CK-1) and casein kinase-2 (CK-2), have been characterized from many sources.
CK1 kinases exist in at least seven isoforms (α, β, γ1-3, δ, and ɛ) in mammals and CK1 kinases phosphorylate various substrates to play vital roles in diverse physiological processes such as DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. Casein kinase 2 (CK2) is a highly pleiotropic serine-threonine kinase, which catalyzed phosphorylation of more than 300 proteins that are implicated in regulation of many cellular functions, such as signal transduction, transcriptional control, apoptosis, and the cell cycle.
Casein Kinase Isoform Specific Products
All Product Categories
-
Casein Kinase Inhibitors
(201)
View all products
-
Casein Kinase Antagonists
(2)
View all products
-
Casein Kinase Activator
(1)
View all products
-
Casein Kinase Chemical
(1)
View all products
-
Casein Kinase Degraders
(23)
View all products
-
Casein Kinase Substrate
(1)
View all products
-
Casein Kinase Ligand
(1)
View all products
-
Casein Kinase Related Products (247)
Related Products (247)
-
Antibodies (5)
-
Casein Kinase Isoform Comparison
-
SR-1277
0 ImagesSR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer.
-
A-3 hydrochloride
0 ImagesA-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively.
-
Casein Kinase II Inhibitor IV hydrochloride
0 ImagesCat. No.: HY-111378ACAS No.: 2320347-54-2Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation.
-
PF-670462
0 ImagesPF-670462 is a selective CKI ε/δ inhibitor. PF-670462 effectively regulates the phase of the circadian rhythm.
-
LY294002 (Standard)
0 ImagesLY294002 (Standard) is the analytical standard of LY294002. This product is intended for research and analytical applications. LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4?μM. LY294002 is an apoptosis activator.
-
CX-5011 free base
0 ImagesCat. No.: HY-50733CAS No.: 1009821-06-0
-
Umbralisib tosylate
0 ImagesCat. No.: HY-12279ACAS No.: 1532533-72-4Synonyms: TGR-1202 tosylate; RP5264 tosylateUmbralisib (TGR-1202) tosylate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib tosylate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate can be used for haematological malignancies reseach.
-
Umbralisib sulfate
0 ImagesCat. No.: HY-12279BCAS No.: 1532533-75-7Synonyms: TGR-1202 sulfate; RP-5264 sulfateUmbralisib (TGR-1202) sulfate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib sulfate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib sulfate can be used for haematological malignancies reseach.
-
Lenalidomide hydrochloride
0 ImagesCat. No.: HY-A0003ACAS No.: 1243329-97-6Synonyms: CC-5013 hydrochlorideLenalidomide hydrochloride (CC-5013 hydrochloride) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide hydrochloride induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide hydrochloride promotes IL-2 release and effector functions of CD8+ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide hydrochloride can be used in research related to hematological malignancies, acute liver failure and acute kidney injury.
-
APL-5125
0 ImagesCat. No.: HY-178980CAS No.: 2830619-57-1APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC50 of 0.348 nM and a Ki of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer.
-
PF-4800567 hydrochloride
0 ImagesCat. No.: HY-12470ACAS No.: 1391052-28-0PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC50?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways.
-
Emodin-d4
0 ImagesCat. No.: HY-14393SCAS No.: 132796-52-2Synonyms: Frangula emodin-d4Emodin-d4 is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice.
-
Casein kinase 1δ-IN-9
0 ImagesCasein kinase 1δ-IN-9 (compound 737) is a potent casein kinase 1δ (CK1δ/CK15) inhibitor. Casein kinase 1δ-IN-9 can be used for the research of neurodegenerative disorders such as Alzheimer's disease.
-
IQA
0 ImagesCat. No.: HY-117332CAS No.: 391670-48-7Synonyms: CGP-029482IQA (CGP-029482) is a potent and selective protein kinase CK2 inhibitor.
-
Casein kinase 1δ-IN-20
0 ImagesCat. No.: HY-169690CAS No.: 757224-44-5Casein kinase 1δ-IN-20 (compound 427) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-20 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
-
Casein Kinase II Receptor Peptide
0 ImagesCat. No.: HY-P3748CAS No.: 198481-81-1Casein Kinase II Receptor Peptide is a substrate for casein kinase II with an Km value of 500 µM. Casein Kinase II Substrate can be used for measure casein kinase II activity in crude enzyme preparations.
-
CK1δ-IN-10
0 ImagesCat. No.: HY-171298CAS No.: 2765374-31-8CK1δ-IN-10 (Compound 85) is the inhibitor for casein kinase 1 that inhibits CK1δ (CSNKID) with IC50 of 0.255 μM.
-
CCK1-specific peptide substrate acetate
0 ImagesCat. No.: HY-P5526ACCK1-specific peptide substrate acetate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)
-
Casein kinase 1δ-IN-21
0 ImagesCat. No.: HY-169692CAS No.: 782457-22-1Casein kinase 1δ-IN-21 (compound 501) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-21 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
