Cyclophilin
Cyclophilins are enzymes that accelerate the rotation of the peptide bond in front of a proline residue. Cyclophilins are involved in a wide variety of cellular processes such as folding, posttranslational modifications and transport of proteins, assembly of essential cellular protein complexes, and cell signaling. Cyclophilins have been identified in a range of organisms, including mammals, plants, insects, fungi, and bacteria.
The prototypic cyclophilin A (CypA) is the most abundant member of the cyclophilin family in human tissue and the major player in the cellular PPIase activity. CypA as a host cell protein interacts with viral proteins and can thus promote or inhibit viral replication and infection of a variety of RNA viruses, most prominently HIV‐1 and HCV.
Cyclophilin Isoform Specific Products
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Cyclophilin Related Products (47)
Related Products (47)
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Cyclophilin Isoform Comparison
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Cyclosporin A-13C2,d4
0 ImagesCat. No.: HY-B0579S3Synonyms: Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4; CsA-13C2,d4Cyclosporin A-13C2,d4 (Cyclosporine A-13C2,d4) is the deuterated, 13C-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.
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Cyclosporin A acetate-d4
0 ImagesCat. No.: HY-B0579S2Synonyms: Cyclosporine A acetate-d4; Ciclosporin A acetate-d4; CsA acetate-d4Cyclosporin A acetate-d4 (Cyclosporine A acetate-d4) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.
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Cyclosporin A-Derivative 2
0 ImagesCat. No.: HY-P1354CAS No.: 156047-45-9Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
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Cyclosporin A-d12
0 ImagesCat. No.: HY-B0579S5Synonyms: Cyclosporine A-d12; Ciclosporin A-d12; CsA-d12Cyclosporin A-d12 (Cyclosporine A-d12) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.
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CypD-IN-4
0 ImagesCat. No.: HY-151488CAS No.: 3023438-19-6CypD-IN-4 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-4 has CypD affinity with an IC50 value of 0.057 μM. CypD-IN-4 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.
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CypD-IN-7
0 ImagesCat. No.: HY-179417CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research.
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Cyclosporin A-KLH
0 ImagesCat. No.: HY-NP194BCyclosporin A-KLH is a conjugate of Cyclosporin A (HY-B0579) and KLH. Cyclosporin A is an immunosuppressant which binds to the cyclophilin .
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ASP5286
0 ImagesCat. No.: HY-P3351CAS No.: 935735-70-9ASP5286 is a novel non-immunosuppressive cyclophilin inhibitor for the research of HCV.
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CypD-IN-3
0 ImagesCat. No.: HY-151487CAS No.: 2651994-75-9CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.
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CypE-IN-1
0 ImagesCat. No.: HY-151489CAS No.: 3023438-33-4CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.
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CypD-IN-6
0 ImagesCat. No.: HY-179416CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM). CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.
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CypB-IN-1
0 ImagesCat. No.: HY-173265CypB-IN-1 (Compound 11) is an inhibitor of cyclophilin B (cyclophilin B) with a Kd value of 12 nM. CypB-IN-1 can be applied to the research field of metabolic dysfunction-associated steatohepatitis (MASH) and the liver fibrosis diseases resulting from it.
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SMCypI C31
0 ImagesCat. No.: HY-125182CAS No.: 2649904-85-6SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction.
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PROTAC CG167
0 ImagesCat. No.: HY-173009PROTAC CG167 is a selective bifunctional PROTAC degrader targeting CypA, with a DC50 of 123 nM. PROTAC CG167 drives ubiquitin-dependent and ubiquitin-like modification-dependent proteasomal degradation of CypA by recruiting the VHL E3 ligase complex. PROTAC CG167 exhibits anti-HIV‑1 and anti-HCV replication activities, and selectively reduces CypA levels in various cells. PROTAC CG167 can be used in studies related to viral infections.
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Cyclophilin inhibitor 3
0 ImagesCat. No.: HY-146648CAS No.: 1676100-30-3Cyclophilin inhibitor 3 (compound 7c) is a potent cyclophilin A (CypA) inhibitor with an potent anti-HCV activity (EC50 of 4.2 μM).
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CypD-IN-29
0 ImagesCat. No.: HY-136804CAS No.: 1115335-95-9CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP).
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Pan-RAS-IN-5
0 ImagesCat. No.: HY-162536Pan-RAS-IN-5 is a macrocyclic pan-RAS inhibitor that targets mutant RAS (including KRAS, NRAS, and HRAS). Pan-RAS-IN-5 inhibits the proliferation of various KRAS-mutant cancer cells. Pan-RAS-IN-5 is applicable to the research of KRAS mutation-related cancers such as pancreatic cancer, nephroblastoma, and colon adenocarcinoma.
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Cyclosporin A-OVA
0 ImagesCat. No.: HY-NP194ACyclosporin A-OVA is a conjugate of Cyclosporin A (HY-B0579) and OVA. Cyclosporin A is an immunosuppressant which binds to the cyclophilin .
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ZX-J-19L
0 ImagesZX-J-19L is a CyPJ inhibitor with inhibitory activity against a variety of tumor cell lines. ZX-J-19L inhibits the growth of human liver cancer cells, human breast cancer cells, ovarian cancer cells and prostate cancer cells in vitro. ZX-J-19L can be used for tumor research.
