2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. DYRK
  5. HIPK Isoform
  6. HIPK Inhibitor

HIPK Inhibitor

HIPK Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-179378
    XRF-1021
    		Inhibitor
    XRF-1021 is an orally active HIPK2 inhibitor (IC50 = 0.18 μM). XRF-1021 reduces the expression of fibrotic markers in TGF-β1 stimulated NRK-49F and HK-2 cells, including Fibronectin, Collagen I and α-SMA. XRF-1021 blocks TGF-β, NF-κB, p53, Wnt/β-catenin, and Notch signaling. XRF-1021 reduces renal injury and fibrosis in vivo. XRF-1021 can be used for the research of chronic kidney disease.
  • HY-177416
    MU1787
    		Inhibitor
    MU1787 is a highly selective homeodomain-interacting protein kinase (HIPK) inhibitor with a furopyridine core, and shows improved selectivity against CLKs, with inactivity against DYRK1B, DYRK2, and MLK2/3 in in vitro cellular assays. MU1787 can be used for the research of malignancies.