D₂ Receptor Agonist

D₂ Receptor Agonists (37):

Cat. No.	Product Name	Effect	Purity

HY-14546

Aripiprazole	Agonist	99.93%
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist.

HY-13720A

Pergolide mesylate	Agonist	99.92%
Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D₁ and D₂ receptors agonist.

HY-15780

Brexpiprazole	Agonist	99.85%
Brexpiprazole (OPC-34712), an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively.

HY-120920

UNC9995	Agonist	99.38%
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2.

HY-108237

Naxagolide

Agonist

99.81%

Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (HY-15296

Cabergoline

Agonist 99.80%

Cabergoline is an ergot derived-dopamine D₂-like receptor agonist that has high affinity for D₂, D₃, and 5-HT_2B receptors (K_i=0.7, 1.5, and 1.2, respectively).

HY-B0410

Pramipexole

Agonist 99.95%

Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively.

HY-75502

Rotigotine

Agonist 99.98%

Rotigotine is a potent dopamine receptor agonist with K_i values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor.

HY-B0623A

Ropinirole hydrochloride

Agonist 99.85%

Ropinirole (SKF 101468) hydrochloride is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor.

HY-12707

Piribedil

Agonist 99.33%

Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist.

HY-111385

UNC9994 hydrochloride

Agonist 98.83%

UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D₂ receptor (D₂R) agonist that selectively activates β-arrestin recruitment and signaling.

HY-109112

Brilaroxazine

Agonist 98.29%

Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator.

HY-100820

Sarizotan

Agonist 98.74%

Sarizotan (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist.

HY-A0007

Rotigotine Hydrochloride

Agonist 99.65%

Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_i of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-N0049

Nuciferine

Agonist 99.46%

Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-B0410A

Pramipexole dihydrochloride hydrate

Agonist ≥98.0%

Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively.

HY-15394

(Rac)-Rotigotine hydrochloride

Agonist 98.66%

(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine.

HY-A0008

Talipexole dihydrochloride

Agonist 99.88%

Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

HY-130344

SKF83959

Agonist

SKF83959 is a potent and selective dopamine D₁-like receptor partial agonist.

HY-103429

Quinelorane dihydrochloride

Agonist ≥99.0%

Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist.

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D2 Receptor Agonist

D2 Receptor Agonists (37):

D₂ Receptor Agonist

D₂ Receptor Agonists (37):